Subversion of actin dynamics by EPEC and EHEC

E Caron, VF Crepini, N Simpson, Stuart Knutton, J Garmendia, G Frankel

    Research output: Contribution to journalReview article

    151 Citations (Scopus)


    During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC, respectively) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes. Much progress has been made recently in our understanding of how EPEC and EHEC regulate the pathways leading to local activation of two regulators of actin cytoskeleton dynamics, the Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex. A recent highlight is the unravelling of functions for effector proteins (particularly Tir, TccP, Map and EspG/EspG2) that are injected into the host cell by a type III secretion system.
    Original languageEnglish
    Pages (from-to)40-45
    Number of pages6
    JournalCurrent Opinion in Microbiology
    Issue number1
    Publication statusPublished - 1 Feb 2006


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