TY - JOUR
T1 - Subversion of actin dynamics by EPEC and EHEC
AU - Caron, E
AU - Crepini, VF
AU - Simpson, N
AU - Knutton, Stuart
AU - Garmendia, J
AU - Frankel, G
PY - 2006/2/1
Y1 - 2006/2/1
N2 - During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC, respectively) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes. Much progress has been made recently in our understanding of how EPEC and EHEC regulate the pathways leading to local activation of two regulators of actin cytoskeleton dynamics, the Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex. A recent highlight is the unravelling of functions for effector proteins (particularly Tir, TccP, Map and EspG/EspG2) that are injected into the host cell by a type III secretion system.
AB - During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC, respectively) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes. Much progress has been made recently in our understanding of how EPEC and EHEC regulate the pathways leading to local activation of two regulators of actin cytoskeleton dynamics, the Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex. A recent highlight is the unravelling of functions for effector proteins (particularly Tir, TccP, Map and EspG/EspG2) that are injected into the host cell by a type III secretion system.
U2 - 10.1016/j.mib.2005.12.006
DO - 10.1016/j.mib.2005.12.006
M3 - Review article
C2 - 16406772
VL - 9
SP - 40
EP - 45
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 1
ER -