Substituent control over dimerization affinity of triply hydrogen bonded heterodimers

Adam Gooch; Andrea M. McGhee; Maria L. Pellizzaro; Christopher I. Lindsay; Andrew J. Wilson

doi:10.1021/ol102619u

Substituent control over dimerization affinity of triply hydrogen bonded heterodimers

Adam Gooch, Andrea M. McGhee, Maria L. Pellizzaro, Christopher I. Lindsay, Andrew J. Wilson

Chemistry

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Linear arrays of hydrogen bonds represent important elements of the supramolecular toolkit for receptor design, assembly of supramolecular polymers, and other well-defined supramolecular structures. It is illustrated that remote substituent effects control dimerization affinity in a predictable manner using a conformer independent ureidoimidazole DDA motif and its amidoisocytosine based AAD partner.

Original language	English
Pages (from-to)	240-243
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	2
DOIs	https://doi.org/10.1021/ol102619u
Publication status	Published - 21 Jan 2011

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol102619u

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title = "Substituent control over dimerization affinity of triply hydrogen bonded heterodimers",

abstract = "Linear arrays of hydrogen bonds represent important elements of the supramolecular toolkit for receptor design, assembly of supramolecular polymers, and other well-defined supramolecular structures. It is illustrated that remote substituent effects control dimerization affinity in a predictable manner using a conformer independent ureidoimidazole DDA motif and its amidoisocytosine based AAD partner.",

author = "Adam Gooch and McGhee, {Andrea M.} and Pellizzaro, {Maria L.} and Lindsay, {Christopher I.} and Wilson, {Andrew J.}",

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AU - Gooch, Adam

AU - McGhee, Andrea M.

AU - Pellizzaro, Maria L.

AU - Lindsay, Christopher I.

AU - Wilson, Andrew J.

PY - 2011/1/21

Y1 - 2011/1/21

N2 - Linear arrays of hydrogen bonds represent important elements of the supramolecular toolkit for receptor design, assembly of supramolecular polymers, and other well-defined supramolecular structures. It is illustrated that remote substituent effects control dimerization affinity in a predictable manner using a conformer independent ureidoimidazole DDA motif and its amidoisocytosine based AAD partner.

AB - Linear arrays of hydrogen bonds represent important elements of the supramolecular toolkit for receptor design, assembly of supramolecular polymers, and other well-defined supramolecular structures. It is illustrated that remote substituent effects control dimerization affinity in a predictable manner using a conformer independent ureidoimidazole DDA motif and its amidoisocytosine based AAD partner.

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SP - 240

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JO - Organic Letters

JF - Organic Letters

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Substituent control over dimerization affinity of triply hydrogen bonded heterodimers

Abstract

ASJC Scopus subject areas

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