STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells

Simon P Newman; Paul A Foster; Chloe Stengel; Joanna M Day; Yaik T Ho; Jean-Gabriel Judde; Myriam Lassalle; Gregoire Prevost; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit

doi:10.1158/1078-0432.CCR-07-1717

STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells

Simon P Newman
, Paul A Foster
, Chloe Stengel
, Joanna M Day
, Yaik T Ho
, Jean-Gabriel Judde
, Myriam Lassalle
, Gregoire Prevost
, Mathew P Leese
, Barry V L Potter
, Michael J Reed
, Atul Purohit

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The aim of these studies was to characterize the action of STX140 in a P-glycoprotein-overexpressing tumor cell line both in vitro and in vivo. In addition, its efficacy was determined against xenografts derived from patients who failed docetaxel therapy.

Original language	English
Pages (from-to)	597-606
Number of pages	10
Journal	Clinical Cancer Research
Volume	14
Issue number	2
DOIs	https://doi.org/10.1158/1078-0432.CCR-07-1717
Publication status	Published - 2008

Access to Document

10.1158/1078-0432.CCR-07-1717

Cite this

@article{88ccc8ed365d47d980983d247e712aa4,

title = "STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells",

abstract = "The aim of these studies was to characterize the action of STX140 in a P-glycoprotein-overexpressing tumor cell line both in vitro and in vivo. In addition, its efficacy was determined against xenografts derived from patients who failed docetaxel therapy.",

author = "Newman, \{Simon P\} and Foster, \{Paul A\} and Chloe Stengel and Day, \{Joanna M\} and Ho, \{Yaik T\} and Jean-Gabriel Judde and Myriam Lassalle and Gregoire Prevost and Leese, \{Mathew P\} and Potter, \{Barry V L\} and Reed, \{Michael J\} and Atul Purohit",

year = "2008",

doi = "10.1158/1078-0432.CCR-07-1717",

language = "English",

volume = "14",

pages = "597--606",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research",

number = "2",

}

TY - JOUR

T1 - STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells

AU - Newman, Simon P

AU - Foster, Paul A

AU - Stengel, Chloe

AU - Day, Joanna M

AU - Ho, Yaik T

AU - Judde, Jean-Gabriel

AU - Lassalle, Myriam

AU - Prevost, Gregoire

AU - Leese, Mathew P

AU - Potter, Barry V L

AU - Reed, Michael J

AU - Purohit, Atul

PY - 2008

Y1 - 2008

N2 - The aim of these studies was to characterize the action of STX140 in a P-glycoprotein-overexpressing tumor cell line both in vitro and in vivo. In addition, its efficacy was determined against xenografts derived from patients who failed docetaxel therapy.

AB - The aim of these studies was to characterize the action of STX140 in a P-glycoprotein-overexpressing tumor cell line both in vitro and in vivo. In addition, its efficacy was determined against xenografts derived from patients who failed docetaxel therapy.

U2 - 10.1158/1078-0432.CCR-07-1717

DO - 10.1158/1078-0432.CCR-07-1717

M3 - Article

C2 - 18223236

SN - 1078-0432

VL - 14

SP - 597

EP - 606

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 2

ER -

STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells

Abstract

Access to Document

Fingerprint

Cite this