STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells

Simon P Newman, Paul A Foster, Chloe Stengel, Joanna M Day, Yaik T Ho, Jean-Gabriel Judde, Myriam Lassalle, Gregoire Prevost, Mathew P Leese, Barry V L Potter, Michael J Reed, Atul Purohit

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)

    Abstract

    The aim of these studies was to characterize the action of STX140 in a P-glycoprotein-overexpressing tumor cell line both in vitro and in vivo. In addition, its efficacy was determined against xenografts derived from patients who failed docetaxel therapy.
    Original languageEnglish
    Pages (from-to)597-606
    Number of pages10
    JournalClinical Cancer Research
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - 2008

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