Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR

Keyphrases

• Structure-based Design 100%
• INPHARMA 100%
• Phosphodiesterase 10A (PDE10A) 100%
• Cyclic GMP 40%
• Huntington's Disease 20%
• Cell Behavior 20%
• Intermolecular Interactions 20%
• NMR Techniques 20%
• High Content 20%
• Water Content 20%
• Ligand-binding Domain 20%
• Tight-binding 20%
• Cyclic Adenosine Monophosphate (cAMP) 20%
• Phosphodiesterase 20%
• Binding Ligand 20%
• Schizophrenia Symptoms 20%
• Binding Pocket 20%
• Binding Fragment 20%
• Water-mediated 20%
• Novel Chemicals 20%
• Chemical Scaffolds 20%
• Structure-based Drug Design 20%
• Ensemble Docking 20%
• Conserved Water Molecules 20%
• ZINC Database 20%
• Via Structure 20%
• Pharmacophore Model 20%
• Pharmacophoric Features 20%

Biochemistry, Genetics and Molecular Biology

• PDE10A 100%
• Cyclic Adenosine Monophosphate 60%
• Cyclic Guanosine Monophosphate 40%
• Cell Function 20%
• Ligand Binding 20%
• Enzymatic Hydrolysis 20%
• Binding Domain 20%
• Phosphodiesterase 20%
• Pharmacophore 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Structure-Based Drug Design 50%