Structure and function of bacterial H-NS protein

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33 Citations (Scopus)


The histone-like nucleoid structuring (H-NS) protein is a major component of the folded chromosome in Escherichia coli and related bacteria. Functions attributed to H-NS include management of genome evolution, DNA condensation, and transcription. The wide-ranging influence of H-NS is remarkable given the simplicity of the protein, a small peptide, possessing rudimentary determinants for self-association, hetero-oligomerisation and DNA binding. In this review, I will discuss our understanding of H-NS with a focus on these structural elements. In particular, I will consider how these interaction surfaces allow H-NS to exert its different effects.

Original languageEnglish
Pages (from-to)1561-1569
Number of pages9
JournalBiochemical Society Transactions
Issue number6
Early online date2 Dec 2016
Publication statusPublished - 15 Dec 2016


  • Review
  • Journal Article


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