Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

Claudio Donati; N Luisa Hiller; Hervé Tettelin; Alessandro Muzzi; Nicholas J Croucher; Samuel V Angiuoli; Marco Oggioni; Julie C Dunning Hotopp; Fen Z Hu; David R Riley; Antonello Covacci; Tim J Mitchell; Stephen D Bentley; Morgens Kilian; Garth D Ehrlich; Rino Rappuoli; E Richard Moxon; Vega Masignani

doi:10.1186/gb-2010-11-10-r107

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

Claudio Donati, N Luisa Hiller, Hervé Tettelin, Alessandro Muzzi, Nicholas J Croucher, Samuel V Angiuoli, Marco Oggioni, Julie C Dunning Hotopp, Fen Z Hu, David R Riley, Antonello Covacci, Tim J Mitchell, Stephen D Bentley, Morgens Kilian, Garth D Ehrlich, Rino Rappuoli, E Richard Moxon, Vega Masignani

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

240 Citations (Scopus)

Abstract

Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group.

Original language	English
Pages (from-to)	R107
Journal	Genome Biology
Volume	11
Issue number	10
DOIs	https://doi.org/10.1186/gb-2010-11-10-r107
Publication status	Published - 2010

Keywords

DNA, Bacterial
Evolution, Molecular
Gene Conversion
Genes, Bacterial
Genetic Variation
Genome, Bacterial
Linkage Disequilibrium
Multigene Family
Phylogeny
Polymorphism, Single Nucleotide
Sequence Alignment
Sequence Analysis, DNA
Streptococcus mitis
Streptococcus pneumoniae
Virulence

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Donati, C., Hiller, N. L., Tettelin, H., Muzzi, A., Croucher, N. J., Angiuoli, S. V., Oggioni, M., Dunning Hotopp, J. C., Hu, F. Z., Riley, D. R., Covacci, A., Mitchell, T. J., Bentley, S. D., Kilian, M., Ehrlich, G. D., Rappuoli, R., Moxon, E. R., & Masignani, V. (2010). Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. Genome Biology, 11(10), R107. https://doi.org/10.1186/gb-2010-11-10-r107

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title = "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species",

abstract = "Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group.",

keywords = "DNA, Bacterial, Evolution, Molecular, Gene Conversion, Genes, Bacterial, Genetic Variation, Genome, Bacterial, Linkage Disequilibrium, Multigene Family, Phylogeny, Polymorphism, Single Nucleotide, Sequence Alignment, Sequence Analysis, DNA, Streptococcus mitis, Streptococcus pneumoniae, Virulence",

author = "Claudio Donati and Hiller, {N Luisa} and Herv{\'e} Tettelin and Alessandro Muzzi and Croucher, {Nicholas J} and Angiuoli, {Samuel V} and Marco Oggioni and {Dunning Hotopp}, {Julie C} and Hu, {Fen Z} and Riley, {David R} and Antonello Covacci and Mitchell, {Tim J} and Bentley, {Stephen D} and Morgens Kilian and Ehrlich, {Garth D} and Rino Rappuoli and Moxon, {E Richard} and Vega Masignani",

year = "2010",

doi = "10.1186/gb-2010-11-10-r107",

language = "English",

volume = "11",

pages = "R107",

journal = "Genome Biology",

issn = "1465-6906",

publisher = "BioMed Central",

number = "10",

}

Donati, C, Hiller, NL, Tettelin, H, Muzzi, A, Croucher, NJ, Angiuoli, SV, Oggioni, M, Dunning Hotopp, JC, Hu, FZ, Riley, DR, Covacci, A, Mitchell, TJ, Bentley, SD, Kilian, M, Ehrlich, GD, Rappuoli, R, Moxon, ER & Masignani, V 2010, 'Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species', Genome Biology, vol. 11, no. 10, pp. R107. https://doi.org/10.1186/gb-2010-11-10-r107

TY - JOUR

T1 - Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

AU - Donati, Claudio

AU - Hiller, N Luisa

AU - Tettelin, Hervé

AU - Muzzi, Alessandro

AU - Croucher, Nicholas J

AU - Angiuoli, Samuel V

AU - Oggioni, Marco

AU - Dunning Hotopp, Julie C

AU - Hu, Fen Z

AU - Riley, David R

AU - Covacci, Antonello

AU - Mitchell, Tim J

AU - Bentley, Stephen D

AU - Kilian, Morgens

AU - Ehrlich, Garth D

AU - Rappuoli, Rino

AU - Moxon, E Richard

AU - Masignani, Vega

PY - 2010

Y1 - 2010

N2 - Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group.

AB - Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group.

KW - DNA, Bacterial

KW - Evolution, Molecular

KW - Gene Conversion

KW - Genes, Bacterial

KW - Genetic Variation

KW - Genome, Bacterial

KW - Linkage Disequilibrium

KW - Multigene Family

KW - Phylogeny

KW - Polymorphism, Single Nucleotide

KW - Sequence Alignment

KW - Sequence Analysis, DNA

KW - Streptococcus mitis

KW - Streptococcus pneumoniae

KW - Virulence

U2 - 10.1186/gb-2010-11-10-r107

DO - 10.1186/gb-2010-11-10-r107

M3 - Article

C2 - 21034474

SN - 1465-6906

VL - 11

SP - R107

JO - Genome Biology

JF - Genome Biology

IS - 10

ER -

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

Abstract

Keywords

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