TY - JOUR
T1 - Structural neuroimaging and the antisocial brain
T2 - Main findings and methodological challenges
AU - de Brito, S.A.
AU - Hodgins, S.
AU - Mccrory, E.J.P.
AU - Mechelli, A.
AU - Wilke, M.
AU - Jones, A.P.
AU - Viding, E.
PY - 2009/11/1
Y1 - 2009/11/1
N2 - A series of neuroimaging studies have reported structural differences in several subcortical and frontal systems in individuals with stable antisocial behavior (sASB). Specifically, differences have been observed in the prefrontal and temporal cortices (e.g., amygdala and hippocampus). However, the sASB population is typically characterized by co-occurring hyperactivity-inattention symptoms and low cognitive ability. These nuisance variables are likely to complicate the interpretation of findings regarding structural differences associated with sASB. The way in which each study deals with these variables influences the conclusions that can be drawn about the brain structure and function of children and adults with sASB. This article briefly reviews the extant literature in this field before considering two approaches that may be used to deal with comorbidities conceptualized as nuisance variables--namely, the analysis of covariance (ANCOVA) and the matched-group design. Then, the authors illustrate, with their own data, checks that may be performed to ensure the validity of results using ANCOVA.
AB - A series of neuroimaging studies have reported structural differences in several subcortical and frontal systems in individuals with stable antisocial behavior (sASB). Specifically, differences have been observed in the prefrontal and temporal cortices (e.g., amygdala and hippocampus). However, the sASB population is typically characterized by co-occurring hyperactivity-inattention symptoms and low cognitive ability. These nuisance variables are likely to complicate the interpretation of findings regarding structural differences associated with sASB. The way in which each study deals with these variables influences the conclusions that can be drawn about the brain structure and function of children and adults with sASB. This article briefly reviews the extant literature in this field before considering two approaches that may be used to deal with comorbidities conceptualized as nuisance variables--namely, the analysis of covariance (ANCOVA) and the matched-group design. Then, the authors illustrate, with their own data, checks that may be performed to ensure the validity of results using ANCOVA.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-70350433093&partnerID=8YFLogxK
U2 - 10.1177/0093854809342883
DO - 10.1177/0093854809342883
M3 - Article
AN - SCOPUS:70350433093
SN - 0093-8548
VL - 36
SP - 1173
EP - 1186
JO - Criminal Justice and Behavior
JF - Criminal Justice and Behavior
IS - 11
ER -