TY - JOUR
T1 - Structural details of the glycosyltransferase step of peptidoglycan assembly
AU - Lovering, Andrew
AU - Gretes, M
AU - Strynadka, NC
PY - 2008/10/1
Y1 - 2008/10/1
N2 - The importance of peptidoglycan in forming the basis of the bacterial cell wall has led to many studies investigating its synthesis. The step of cross-linkage via transpeptidation, and its inhibition by penicillins, has been extremely well characterized yet knowledge of the preceding glycosyltransfer reaction remained elusive until recently. The structures of two glycosyltransferase enzymes, catalyzing membrane-based polymerization of the lipid II monomer unit, have presented a means of elucidating the molecular details of this highly desirable antibiotic target. Evidence acquired before the publication of the structures is related here to these new findings, with particular emphasis on the recognition of substrates and inhibitors.
AB - The importance of peptidoglycan in forming the basis of the bacterial cell wall has led to many studies investigating its synthesis. The step of cross-linkage via transpeptidation, and its inhibition by penicillins, has been extremely well characterized yet knowledge of the preceding glycosyltransfer reaction remained elusive until recently. The structures of two glycosyltransferase enzymes, catalyzing membrane-based polymerization of the lipid II monomer unit, have presented a means of elucidating the molecular details of this highly desirable antibiotic target. Evidence acquired before the publication of the structures is related here to these new findings, with particular emphasis on the recognition of substrates and inhibitors.
U2 - 10.1016/j.sbi.2008.07.002
DO - 10.1016/j.sbi.2008.07.002
M3 - Review article
C2 - 18721881
SN - 1879-033X
VL - 18
SP - 534
EP - 543
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 5
ER -