Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant

RV Tatituri; Luke Alderwick; Arun Kumar Mishra; J Nigou; M Gilleron; K Krumbach; P Hitchen; A Giordano; HR Morris; A Dell; L Eggeling; Gurdyal Besra

doi:10.1099/mic.0.2007/008078-0

Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant

RV Tatituri
, Luke Alderwick
, Arun Kumar Mishra
, J Nigou
, M Gilleron
, K Krumbach
, P Hitchen
, A Giordano
, HR Morris
, A Dell
, L Eggeling
, Gurdyal Besra

Biosciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

220 Downloads (Pure)

Abstract

Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM). Herein, we show by quantitative sugar and glycosyl linkage analysis that C. glutamicum possesses a much smaller LAM version, Cg-LAM, characterised by single t-Araf residues linked to the

Original language	English
Pages (from-to)	2621-2629
Number of pages	9
Journal	Microbiology
Volume	153
Issue number	8
DOIs	https://doi.org/10.1099/mic.0.2007/008078-0
Publication status	Published - 1 Aug 2007

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Tatituri_Revised_Micro.pdf

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Tatituri, RV., Alderwick, L., Mishra, A. K., Nigou, J., Gilleron, M., Krumbach, K., Hitchen, P., Giordano, A., Morris, HR., Dell, A., Eggeling, L., & Besra, G. (2007). Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant. Microbiology, 153(8), 2621-2629. https://doi.org/10.1099/mic.0.2007/008078-0

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title = "Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant",

abstract = "Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM). Herein, we show by quantitative sugar and glycosyl linkage analysis that C. glutamicum possesses a much smaller LAM version, Cg-LAM, characterised by single t-Araf residues linked to the",

author = "RV Tatituri and Luke Alderwick and Mishra, \{Arun Kumar\} and J Nigou and M Gilleron and K Krumbach and P Hitchen and A Giordano and HR Morris and A Dell and L Eggeling and Gurdyal Besra",

year = "2007",

month = aug,

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doi = "10.1099/mic.0.2007/008078-0",

language = "English",

volume = "153",

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Tatituri, RV, Alderwick, L, Mishra, AK, Nigou, J, Gilleron, M, Krumbach, K, Hitchen, P, Giordano, A, Morris, HR, Dell, A, Eggeling, L & Besra, G 2007, 'Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant', Microbiology, vol. 153, no. 8, pp. 2621-2629. https://doi.org/10.1099/mic.0.2007/008078-0

TY - JOUR

T1 - Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant

AU - Tatituri, RV

AU - Alderwick, Luke

AU - Mishra, Arun Kumar

AU - Nigou, J

AU - Gilleron, M

AU - Krumbach, K

AU - Hitchen, P

AU - Giordano, A

AU - Morris, HR

AU - Dell, A

AU - Eggeling, L

AU - Besra, Gurdyal

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM). Herein, we show by quantitative sugar and glycosyl linkage analysis that C. glutamicum possesses a much smaller LAM version, Cg-LAM, characterised by single t-Araf residues linked to the

AB - Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM). Herein, we show by quantitative sugar and glycosyl linkage analysis that C. glutamicum possesses a much smaller LAM version, Cg-LAM, characterised by single t-Araf residues linked to the

U2 - 10.1099/mic.0.2007/008078-0

DO - 10.1099/mic.0.2007/008078-0

M3 - Article

C2 - 17660426

SN - 1465-2080

VL - 153

SP - 2621

EP - 2629

JO - Microbiology

JF - Microbiology

IS - 8

ER -

Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant

Abstract

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