Abstract
The intraocular pressure (IOP) is a physiological parameter that plays a crucial role in preventing, diagnosing, and treating ocular diseases. For example, lowering the IOP is the primary focus of glaucoma management. However, IOP is a widely varying parameter, and one-off measurements are prompt to errors. Developing portable solutions for continuous monitoring the IOP is a critical goal in ophthalmology. Here, stretchable nanostructures were developed as strain-tunable diffraction gratings and integrated into a contact lens. They exhibited a limit of detection (LOD) <2 mmHg and a linear response in the range of interest (15-35 mmHg). Nanopatterns were characterized under monochromatic laser sources and further integrated into a soft contact lens. A smartphone readout method based on preferentially reflected colors was proposed to pave the way toward smartphone-based ocular health monitoring.
| Original language | English |
|---|---|
| Pages (from-to) | 5416-5424 |
| Number of pages | 9 |
| Journal | ACS Applied Polymer Materials |
| Volume | 3 |
| Issue number | 11 |
| Early online date | 7 Oct 2021 |
| DOIs | |
| Publication status | Published - 12 Nov 2021 |
Bibliographical note
Funding Information:R.M. acknowledges the School of Chemical Engineering at the University of Birmingham for funding. P.M.M. acknowledges financial support by the ERC (Consolidator Grant 614787). A.K.Y. thanks the Engineering and Physical Sciences Research Council (EPSRC) for a New Investigator Award (EP/T013567/1).
Keywords
- contact lenses
- diffraction gratings
- glaucoma
- intraocular pressure (IOP)
- nanopillars
ASJC Scopus subject areas
- Polymers and Plastics
- Process Chemistry and Technology
- Organic Chemistry