Streptococcus pneumoniae: virulence factors and variation

A M Mitchell, T J Mitchell

Research output: Contribution to journalArticlepeer-review

164 Citations (Scopus)


Streptococcus pneumoniae is a major pathogen of humans, causing diseases such as pneumonia and meningitis. The organism produces several virulence factors that are involved in the disease process. The molecular basis of the action of some of these virulence factors is being elucidated. The advent of whole genome sequencing combined with biological studies has demonstrated that genome variation is important in the ability of pneumococci to interact with the host. This review discusses the biological activity of several pneumococcal virulence factors, and describes how genome variation may impact on the ability of pneumococci to cause disease.
Original languageEnglish
Pages (from-to)411-8
Number of pages8
JournalClinical Microbiology and Infection
Issue number5
Publication statusPublished - May 2010


  • Genetic Variation
  • Humans
  • Pneumococcal Infections
  • Streptococcus pneumoniae
  • Virulence Factors


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