Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

J R Canvin, J C Paton, G J Boulnois, P W Andrew, T J Mitchell

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.

Original languageEnglish
Pages (from-to)129-32
Number of pages4
JournalMicrobial Pathogenesis
Issue number3
Publication statusPublished - Mar 1997


  • Antibodies, Bacterial
  • Bacterial Proteins
  • Cholesterol
  • Escherichia coli
  • Hemolysin Proteins
  • Hemolysis
  • Streptococcus
  • Streptococcus pneumoniae
  • Streptolysins


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