Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

Setuhn Jimaja; Spyridon Varlas; Jeff Foster; Daniel Taton; Andrew Dove; Rachel O'Reilly

doi:10.1039/D2PY00397J

Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

Setuhn Jimaja, Spyridon Varlas, Jeff Foster, Daniel Taton, Andrew Dove, Rachel O'Reilly

Chemistry

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Abstract

We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.

Original language	English
Pages (from-to)	4047-4053
Number of pages	7
Journal	Polymer Chemistry
Volume	13
Issue number	27
Early online date	13 Jun 2022
DOIs	https://doi.org/10.1039/D2PY00397J
Publication status	Published - 12 Jul 2022

Bibliographical note

Funding Information:
This work was supported by the European Union (SUSPOL-EJD 642671), ERC (grant number 615142), EPSRC, and the University of Birmingham.

Keywords

stimuli-responsive
micelles
diamines

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10.1039/D2PY00397JLicence: Creative Commons: Attribution (CC BY)

JimajaS2022StimuliFinal published version, 1.69 MBLicence: Creative Commons: Attribution (CC BY)

FP7_ERC_SCPS
O'Reilly, R. (Principal Investigator)
European Commission
1/01/18 → 31/05/21
Project: EU

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title = "Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s",

abstract = "We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.",

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author = "Setuhn Jimaja and Spyridon Varlas and Jeff Foster and Daniel Taton and Andrew Dove and Rachel O'Reilly",

note = "Funding Information: This work was supported by the European Union (SUSPOL-EJD 642671), ERC (grant number 615142), EPSRC, and the University of Birmingham.",

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doi = "10.1039/D2PY00397J",

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AU - Varlas, Spyridon

AU - Foster, Jeff

AU - Taton, Daniel

AU - Dove, Andrew

AU - O'Reilly, Rachel

N1 - Funding Information: This work was supported by the European Union (SUSPOL-EJD 642671), ERC (grant number 615142), EPSRC, and the University of Birmingham.

PY - 2022/7/12

Y1 - 2022/7/12

N2 - We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.

AB - We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.

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Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

Abstract

Bibliographical note

Keywords

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FP7_ERC_SCPS

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