TY - JOUR
T1 - Stimulation of human spermatozoa with progesterone gradients to simulate approach to the oocyte. Induction of (Ca(2+))(1) oscillations and cyclical transitions in flagellar beating
AU - Harper, CV
AU - Barratt, Christopher
AU - Publicover, Stephen
PY - 2004/8/11
Y1 - 2004/8/11
N2 - Progesterone is present at micromolar concentrations in the cumulus matrix, which surrounds mammalian oocytes. Exposure of human spermatozoa to a concentration gradient of progesterone (0-3 microM) to simulate approach to the oocyte induced a slowly developing increase in [Ca(2+)](i) upon which, in many cells, slow oscillations were superimposed. [Ca(2+)](i) oscillations often started at very low progesterone (
AB - Progesterone is present at micromolar concentrations in the cumulus matrix, which surrounds mammalian oocytes. Exposure of human spermatozoa to a concentration gradient of progesterone (0-3 microM) to simulate approach to the oocyte induced a slowly developing increase in [Ca(2+)](i) upon which, in many cells, slow oscillations were superimposed. [Ca(2+)](i) oscillations often started at very low progesterone (
U2 - 10.1074/jbc.M401194200
DO - 10.1074/jbc.M401194200
M3 - Article
C2 - 15322137
SN - 1083-351X
VL - 279
SP - 46315
EP - 46325
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 44
ER -