Stage-IIB osteosarcomas around the knee. A study of MMP-9 on surviving tumour cells

AF Foukas, Nayneeta Deshmukh, Robert Grimer, David Mangham, EG Mangos, S Taylor

Research output: Contribution to journalArticle

Abstract

We studied 55 patients with stage-IIB osteosarcoma around the knee with respect to the expression of matrix metalloproteinase (MMP)-9 in the surviving tumour cells in surgical resection specimens. They were followed up for a minimum of 2.5 years. Factors significantly associated with poor overall survival were a high serum level of alkaline phosphatase at diagnosis and tumour cells expressing MMP-9 in the resection specimens. The only factor strongly associated with disease-free survival was the immunohistochemical status of tumour cells for MMP-9 in the resection specimens. The percentage of necrosis after chemotherapy failed marginally to reach statistical significance. On Cox regression analysis only MMP-9 remained significant for overall and disease-free survival.
Original languageEnglish
Pages (from-to)706-711
Number of pages6
JournalJournal of Bone and Joint Surgery (British Volume)
Volume84
Publication statusPublished - 1 Jan 2002

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