Stabilisation of Eudesmane Cation by Tryptophan 334 during Aristolochene Synthase Catalysis

Athina Deligeorgopoulou; Silvia Forcat; Susan Taylor; Rudolf Allemann

doi:10.1039/b306867f

Stabilisation of Eudesmane Cation by Tryptophan 334 during Aristolochene Synthase Catalysis

Athina Deligeorgopoulou, Silvia Forcat, Susan Taylor, Rudolf Allemann

Chemistry

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36 Citations (Scopus)

Abstract

Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.

Original language	English
Pages (from-to)	2162-2163
Number of pages	2
Journal	Chemical Communications
Issue number	17
DOIs	https://doi.org/10.1039/b306867f
Publication status	Published - 1 Jan 2003

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title = "Stabilisation of Eudesmane Cation by Tryptophan 334 during Aristolochene Synthase Catalysis",

abstract = "Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.",

author = "Athina Deligeorgopoulou and Silvia Forcat and Susan Taylor and Rudolf Allemann",

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AU - Taylor, Susan

AU - Allemann, Rudolf

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N2 - Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.

AB - Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.

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JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Stabilisation of Eudesmane Cation by Tryptophan 334 during Aristolochene Synthase Catalysis

Abstract

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