ST273 carbapenem-resistant Klebsiella pneumoniae carrying blaNDM-1 and blaIMP-4

Liu Lu, Yu Feng, Haiyan Long, Alan McNally, Zhiyong Zong

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A carbapenem-resistant Klebsiella pneumoniae was recovered from human blood. Its whole genome sequence was obtained using both Illumina and long-read MinION sequencing. The strain belongs to ST273, which has been found recently and caused an outbreak in Southeast Asia. It has two carbapenemase genes blaNDM-1 (carried by an ST7 IncN self-transmissible plasmid) and blaIMP-4 (located on an self-transmissible IncHI5 plasmid). Non-KPC-producing ST237 may represent a lineage of carbapenem-resistant K. pneumoniae, which warrants further monitoring.

Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Early online date2 Apr 2018
Publication statusE-pub ahead of print - 2 Apr 2018


  • Journal Article


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