Sporogenesis and toxin A production by Clostridium difficile

J M Ketley; T J Mitchell; S C Haslam; J Stephen; D C Candy; D W Burdon

doi:10.1099/00222615-22-1-33

Sporogenesis and toxin A production by Clostridium difficile

J M Ketley, T J Mitchell, S C Haslam, J Stephen, D C Candy, D W Burdon

Microbes, Infection and Microbiomes

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.

Original language	English
Pages (from-to)	33-8
Number of pages	6
Journal	Journal of Medical Microbiology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1099/00222615-22-1-33
Publication status	Published - Aug 1986

Keywords

Bacterial Toxins
Clostridium
Enterotoxins
Kinetics
Spores, Bacterial
Ultrasonics

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10.1099/00222615-22-1-33

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title = "Sporogenesis and toxin A production by Clostridium difficile",

abstract = "The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.",

keywords = "Bacterial Toxins, Clostridium, Enterotoxins, Kinetics, Spores, Bacterial, Ultrasonics",

author = "Ketley, \{J M\} and Mitchell, \{T J\} and Haslam, \{S C\} and J Stephen and Candy, \{D C\} and Burdon, \{D W\}",

year = "1986",

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doi = "10.1099/00222615-22-1-33",

language = "English",

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T1 - Sporogenesis and toxin A production by Clostridium difficile

AU - Ketley, J M

AU - Mitchell, T J

AU - Haslam, S C

AU - Stephen, J

AU - Candy, D C

AU - Burdon, D W

PY - 1986/8

Y1 - 1986/8

N2 - The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.

AB - The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.

KW - Bacterial Toxins

KW - Clostridium

KW - Enterotoxins

KW - Kinetics

KW - Spores, Bacterial

KW - Ultrasonics

UR - https://www.scopus.com/pages/publications/0022469718

U2 - 10.1099/00222615-22-1-33

DO - 10.1099/00222615-22-1-33

M3 - Article

C2 - 3735389

SN - 0022-2615

VL - 22

SP - 33

EP - 38

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

IS - 1

ER -

Sporogenesis and toxin A production by Clostridium difficile

Abstract

Keywords

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