Sporogenesis and toxin A production by Clostridium difficile

J M Ketley, T J Mitchell, S C Haslam, J Stephen, D C Candy, D W Burdon

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6 Citations (Scopus)


The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.

Original languageEnglish
Pages (from-to)33-8
Number of pages6
JournalJournal of Medical Microbiology
Issue number1
Publication statusPublished - Aug 1986


  • Bacterial Toxins
  • Clostridium
  • Enterotoxins
  • Kinetics
  • Spores, Bacterial
  • Ultrasonics


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