South Asian chronic lymphocyticleukaemia patients have more rapid disease progression in comparison to White patients

C Gunawardana; B Austen; Judith Powell; C Fegan; F Wandroo; A Jacobs; Guy Pratt; Paul Moss

doi:10.1111/j.1365-2141.2008.07226.x

South Asian chronic lymphocyticleukaemia patients have more rapid disease progression in comparison to White patients

C Gunawardana, B Austen, Judith Powell, C Fegan, F Wandroo, A Jacobs, Guy Pratt, Paul Moss

Cancer and Genomic Sciences

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20 Citations (Scopus)

Abstract

Ethnicity has a major impact on the prevalence of chronic lymphocytic leukaemia (CLL) and may also influence disease phenotype. We compared the clinical features of Southern Asian and White CLL patients managed within one UK region. Asians required treatment almost twice as often as Whites (HR, 1.94) and had a shorter time to first treatment (P = 0.0063). This difference remained significant after adjusting for stage, lymphocyte doubling time and IGHV status (P = 0.026). CLL was diagnosed at younger ages in Asians and racial-specific variations in IGHV usage were demonstrated. Our findings indicate that Southern Asian race has a negative impact on CLL phenotype.

Original language	English
Journal	British Journal of Haematology
Early online date	22 May 2008
DOIs	https://doi.org/10.1111/j.1365-2141.2008.07226.x
Publication status	Published - 22 May 2008

Keywords

immunoglobulin
chronic lymphocytic leukaemia
survival
outcome
ethnicity

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10.1111/j.1365-2141.2008.07226.x

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title = "South Asian chronic lymphocyticleukaemia patients have more rapid disease progression in comparison to White patients",

abstract = "Ethnicity has a major impact on the prevalence of chronic lymphocytic leukaemia (CLL) and may also influence disease phenotype. We compared the clinical features of Southern Asian and White CLL patients managed within one UK region. Asians required treatment almost twice as often as Whites (HR, 1.94) and had a shorter time to first treatment (P = 0.0063). This difference remained significant after adjusting for stage, lymphocyte doubling time and IGHV status (P = 0.026). CLL was diagnosed at younger ages in Asians and racial-specific variations in IGHV usage were demonstrated. Our findings indicate that Southern Asian race has a negative impact on CLL phenotype.",

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T1 - South Asian chronic lymphocyticleukaemia patients have more rapid disease progression in comparison to White patients

AU - Gunawardana, C

AU - Austen, B

AU - Powell, Judith

AU - Fegan, C

AU - Wandroo, F

AU - Jacobs, A

AU - Pratt, Guy

AU - Moss, Paul

PY - 2008/5/22

Y1 - 2008/5/22

N2 - Ethnicity has a major impact on the prevalence of chronic lymphocytic leukaemia (CLL) and may also influence disease phenotype. We compared the clinical features of Southern Asian and White CLL patients managed within one UK region. Asians required treatment almost twice as often as Whites (HR, 1.94) and had a shorter time to first treatment (P = 0.0063). This difference remained significant after adjusting for stage, lymphocyte doubling time and IGHV status (P = 0.026). CLL was diagnosed at younger ages in Asians and racial-specific variations in IGHV usage were demonstrated. Our findings indicate that Southern Asian race has a negative impact on CLL phenotype.

AB - Ethnicity has a major impact on the prevalence of chronic lymphocytic leukaemia (CLL) and may also influence disease phenotype. We compared the clinical features of Southern Asian and White CLL patients managed within one UK region. Asians required treatment almost twice as often as Whites (HR, 1.94) and had a shorter time to first treatment (P = 0.0063). This difference remained significant after adjusting for stage, lymphocyte doubling time and IGHV status (P = 0.026). CLL was diagnosed at younger ages in Asians and racial-specific variations in IGHV usage were demonstrated. Our findings indicate that Southern Asian race has a negative impact on CLL phenotype.

KW - immunoglobulin

KW - chronic lymphocytic leukaemia

KW - survival

KW - outcome

KW - ethnicity

U2 - 10.1111/j.1365-2141.2008.07226.x

DO - 10.1111/j.1365-2141.2008.07226.x

M3 - Article

C2 - 18503582

SN - 1365-2141

JO - British Journal of Haematology

JF - British Journal of Haematology

ER -

South Asian chronic lymphocyticleukaemia patients have more rapid disease progression in comparison to White patients

Abstract

Keywords

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