TY - JOUR
T1 - SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development
AU - Van Bezooijen, Rutger L.
AU - DeRuiter, Marco C.
AU - Vilain, Nathalie
AU - Monteiro, Rui M.
AU - Visser, Annemieke
AU - Van Der Wee-Pals, Lianne
AU - Van Munsteren, Conny J.
AU - Hogendoorn, Paneras C.W.
AU - Aguet, Michel
AU - Mummery, Christine L.
AU - Papapoulos, Socrates E.
AU - Ten Dijke, Peter
AU - Löwik, Clemens W.G.M.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the present study, we show that SOST, a Dan family member reported to antagonize BMP and Wnt activity, is expressed within the medial vessel wall of the great arteries containing smooth muscle cells. The ascending aorta, aortic arch, brachiocephalic artery, common carotids, and pulmonary trunk were all associated with SOST expressing smooth muscle cells, while the heart itself, including the valves, and more distal arteries, that is, pulmonary arteries, subclavian arteries, and descending aorta, were negative. SOST was expressed from embryonic day 15.5 up to the neonatal period. SOST expression, however, did not correspond with inhibition of Smad-dependent BMP activity or β-catenin-dependent Wnt activity in the great arteries. Activity of both signaling pathways was already down-regulated before induction of SOST expression.
AB - Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the present study, we show that SOST, a Dan family member reported to antagonize BMP and Wnt activity, is expressed within the medial vessel wall of the great arteries containing smooth muscle cells. The ascending aorta, aortic arch, brachiocephalic artery, common carotids, and pulmonary trunk were all associated with SOST expressing smooth muscle cells, while the heart itself, including the valves, and more distal arteries, that is, pulmonary arteries, subclavian arteries, and descending aorta, were negative. SOST was expressed from embryonic day 15.5 up to the neonatal period. SOST expression, however, did not correspond with inhibition of Smad-dependent BMP activity or β-catenin-dependent Wnt activity in the great arteries. Activity of both signaling pathways was already down-regulated before induction of SOST expression.
KW - BMP
KW - Great arteries
KW - Heart development
KW - Outflow tract
KW - SOST
KW - Wnt
UR - http://www.scopus.com/inward/record.url?scp=33846925672&partnerID=8YFLogxK
U2 - 10.1002/dvdy.21054
DO - 10.1002/dvdy.21054
M3 - Article
C2 - 17195180
AN - SCOPUS:33846925672
SN - 1058-8388
VL - 236
SP - 606
EP - 612
JO - Developmental Dynamics
JF - Developmental Dynamics
IS - 2
ER -