Soluble interleukin-2 receptors in retinal vasculitis

P I Murray, D W Young

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Soluble interleukin-2 receptor (sIL-2R) levels were measured in the serum of 27 patients with retinal vasculitis, 16 with vasculitis purely isolated to the eye (RV) and 11 with vasculitis associated with a systemic inflammatory disease (RV+SID). Levels of sIL-2R were statistically significantly increased (mu 986, SD 845 U/ml, p = 0.013) only in the RV+SID group as compared to healthy controls. The highest levels being found in patients with sarcoidosis (mu 1436, SD 1083 U/ml). There was no correlation with disease activity or with systemic corticosteroid therapy. Serum sIL-2R measurements appear to be of limited use in the management of patients with retinal vasculitis, but may be of value in those patients with sarcoidosis. Longitudinal measurements with larger numbers of patients are required to confirm this. Serum sIL-2R levels were also statistically significantly increased (mu 843, SD 171 U/ml, p less than 0.0001) in 21 patients with Fuchs' heterochromic cyclitis. As this is a chronic condition with mild inflammatory activity and no associated systemic disease, the explanation for this finding is unknown.
Original languageEnglish
Pages (from-to)193-5
Number of pages3
JournalCurrent eye research
Volume11 Suppl
Publication statusPublished - 1992


Dive into the research topics of 'Soluble interleukin-2 receptors in retinal vasculitis'. Together they form a unique fingerprint.

Cite this