Solubility of Azoxystrobin and Benflumetol in compressed CO2 - measured by the static precise mass measuring method

Qingguo Li; Piaopiao Pan; Tiejun Lu; Stuart Blackburn; Gary A. Leeke

doi:10.1021/acs.jced.8b00388

Solubility of Azoxystrobin and Benflumetol in compressed CO₂ - measured by the static precise mass measuring method

Qingguo Li, Piaopiao Pan, Tiejun Lu, Stuart Blackburn, Gary A. Leeke^*

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

217 Downloads (Pure)

Abstract

The solubilities of hardly soluble solutes in compressed CO₂ were measured using a new static precise mass measuring (SPMM) method. The solubilities of two solutes - azoxystrobin, a substituted pyrimidine, and benflumetol, an antimalarial drug - were determined at pressures and temperatures from 80 to 250 bar and 301 to 323 K. The solubilities of these two compounds were 64-661 and 1.3-19.7 mg/kg of CO₂, respectively. The measured solubilities were correlated using the density-based model proposed by Chrastil and the theory of dilute solutions-based model proposed by Mendez-Santiago and Teja. A linear relationship between the solubility and the solvent density was obtained.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Journal of Chemical and Engineering Data
Volume	64
Issue number	1
Early online date	20 Dec 2018
DOIs	https://doi.org/10.1021/acs.jced.8b00388
Publication status	E-pub ahead of print - 20 Dec 2018

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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Cite this

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abstract = "The solubilities of hardly soluble solutes in compressed CO2 were measured using a new static precise mass measuring (SPMM) method. The solubilities of two solutes - azoxystrobin, a substituted pyrimidine, and benflumetol, an antimalarial drug - were determined at pressures and temperatures from 80 to 250 bar and 301 to 323 K. The solubilities of these two compounds were 64-661 and 1.3-19.7 mg/kg of CO2, respectively. The measured solubilities were correlated using the density-based model proposed by Chrastil and the theory of dilute solutions-based model proposed by Mendez-Santiago and Teja. A linear relationship between the solubility and the solvent density was obtained.",

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AU - Blackburn, Stuart

AU - Leeke, Gary A.

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AB - The solubilities of hardly soluble solutes in compressed CO2 were measured using a new static precise mass measuring (SPMM) method. The solubilities of two solutes - azoxystrobin, a substituted pyrimidine, and benflumetol, an antimalarial drug - were determined at pressures and temperatures from 80 to 250 bar and 301 to 323 K. The solubilities of these two compounds were 64-661 and 1.3-19.7 mg/kg of CO2, respectively. The measured solubilities were correlated using the density-based model proposed by Chrastil and the theory of dilute solutions-based model proposed by Mendez-Santiago and Teja. A linear relationship between the solubility and the solvent density was obtained.

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