Solubilities of Pharmaceutical Compounds in Ionic Liquids

KB Smith, Rachel Bridson, Gary Leeke

Research output: Contribution to journalArticle

77 Citations (Scopus)


The solubilities of paracetamol and ibuprofen were determined in two different ionic liquids at temperatures of 298.15 K, 308.15 K, 318.15 K, 328.15 K, and 338.15 K. The ionic liquids selected were 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-hexyl-3-methylimidazolium hexafluorophosphate [HMIM][PF6]. In addition, solubility data for paracetamol and ibuprofen in water are reported at the same temperatures extending the data commonly reported in pharmaceutical reference texts. For all solvents the concentration of drug in solution was determined by UV spectrophotometry.
Original languageEnglish
Pages (from-to)2039–2043
JournalJournal of Chemical Engineering Data
Issue number5
Publication statusPublished - 1 Jan 2009


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