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Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

  • Mark D. Eddleston
  • , Mihails Arhangelskis
  • , Tomislav Frišcic
  • , William Jones*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.

Original languageEnglish
Pages (from-to)11340-11342
Number of pages3
JournalChemical Communications
Volume48
Issue number92
DOIs
Publication statusPublished - 24 Oct 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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