Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy (STDR): A Population-Based Cohort Study in the U.K.

Luyuan Tan; Jingya Wang; Jieun Han; Chris Sainsbury; Alastair Denniston; Francesca Crowe; Konstantinos Toulis; Krishnarajah Nirantharakumar; Muhammad Ali Karamat; Mi Yao

doi:10.2337/dc23-1626

Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy (STDR): A Population-Based Cohort Study in the U.K.

Luyuan Tan
, Jingya Wang^*
, Jieun Han
, Chris Sainsbury
, Alastair Denniston
, Francesca Crowe
, Konstantinos Toulis
, Krishnarajah Nirantharakumar^*
, Muhammad Ali Karamat
, Mi Yao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

197 Downloads (Pure)

Abstract

OBJECTIVE
To evaluate the associations between socioeconomic deprivation and sight-threatening diabetic retinopathy (STDR) in individuals with type 1 (T1D) and type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
Data from 175,628 individuals with diabetes in the Health Improvement Network were used to assess the risk of STDR across Townsend Deprivation Index quantiles using Cox proportional hazard regression.

RESULTS
Among individuals with T1D, the risk of STDR was three times higher (adjusted hazard ratio [aHR] 2.67, 95% CI 1.05–7.78) in the most deprived quintile compared with the least deprived quintile. In T2D, the most deprived quintile had a 28% higher risk (aHR 1.28; 95% CI 1.15–1.43) than the least deprived quintile.

CONCLUSIONS
Increasing socioeconomic deprivation is associated with a higher risk of developing STDR in people with diabetes. This underscores persistent health disparities linked to poverty, even within a country offering free universal health care. Further research is needed to address health equity concerns in socioeconomically deprived regions.

Original language	English
Article number	dc231626
Journal	Diabetes Care
Early online date	22 Feb 2024
DOIs	https://doi.org/10.2337/dc23-1626
Publication status	E-pub ahead of print - 22 Feb 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.2337/dc23-1626Licence: None: All rights reserved

TanL2024Socioeconomic_AAM
This is an accepted manuscript version of an article first published in Diabetes Care. The final version of record is available at https://doi.org/10.2337/dc23-1626
Accepted author manuscript, 282 KBLicence: Other (please specify with Rights Statement)

Cite this

@article{337a64bc06104cb391c7e7d09c01f378,

title = "Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy (STDR): A Population-Based Cohort Study in the U.K.",

abstract = "OBJECTIVE To evaluate the associations between socioeconomic deprivation and sight-threatening diabetic retinopathy (STDR) in individuals with type 1 (T1D) and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Data from 175,628 individuals with diabetes in the Health Improvement Network were used to assess the risk of STDR across Townsend Deprivation Index quantiles using Cox proportional hazard regression. RESULTS Among individuals with T1D, the risk of STDR was three times higher (adjusted hazard ratio [aHR] 2.67, 95\% CI 1.05–7.78) in the most deprived quintile compared with the least deprived quintile. In T2D, the most deprived quintile had a 28\% higher risk (aHR 1.28; 95\% CI 1.15–1.43) than the least deprived quintile. CONCLUSIONS Increasing socioeconomic deprivation is associated with a higher risk of developing STDR in people with diabetes. This underscores persistent health disparities linked to poverty, even within a country offering free universal health care. Further research is needed to address health equity concerns in socioeconomically deprived regions.",

author = "Luyuan Tan and Jingya Wang and Jieun Han and Chris Sainsbury and Alastair Denniston and Francesca Crowe and Konstantinos Toulis and Krishnarajah Nirantharakumar and Karamat, \{Muhammad Ali\} and Mi Yao",

year = "2024",

month = feb,

day = "22",

doi = "10.2337/dc23-1626",

language = "English",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

}

TY - JOUR

T1 - Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy (STDR)

T2 - A Population-Based Cohort Study in the U.K.

AU - Tan, Luyuan

AU - Wang, Jingya

AU - Han, Jieun

AU - Sainsbury, Chris

AU - Denniston, Alastair

AU - Crowe, Francesca

AU - Toulis, Konstantinos

AU - Nirantharakumar, Krishnarajah

AU - Karamat, Muhammad Ali

AU - Yao, Mi

PY - 2024/2/22

Y1 - 2024/2/22

N2 - OBJECTIVE To evaluate the associations between socioeconomic deprivation and sight-threatening diabetic retinopathy (STDR) in individuals with type 1 (T1D) and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Data from 175,628 individuals with diabetes in the Health Improvement Network were used to assess the risk of STDR across Townsend Deprivation Index quantiles using Cox proportional hazard regression. RESULTS Among individuals with T1D, the risk of STDR was three times higher (adjusted hazard ratio [aHR] 2.67, 95% CI 1.05–7.78) in the most deprived quintile compared with the least deprived quintile. In T2D, the most deprived quintile had a 28% higher risk (aHR 1.28; 95% CI 1.15–1.43) than the least deprived quintile. CONCLUSIONS Increasing socioeconomic deprivation is associated with a higher risk of developing STDR in people with diabetes. This underscores persistent health disparities linked to poverty, even within a country offering free universal health care. Further research is needed to address health equity concerns in socioeconomically deprived regions.

AB - OBJECTIVE To evaluate the associations between socioeconomic deprivation and sight-threatening diabetic retinopathy (STDR) in individuals with type 1 (T1D) and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Data from 175,628 individuals with diabetes in the Health Improvement Network were used to assess the risk of STDR across Townsend Deprivation Index quantiles using Cox proportional hazard regression. RESULTS Among individuals with T1D, the risk of STDR was three times higher (adjusted hazard ratio [aHR] 2.67, 95% CI 1.05–7.78) in the most deprived quintile compared with the least deprived quintile. In T2D, the most deprived quintile had a 28% higher risk (aHR 1.28; 95% CI 1.15–1.43) than the least deprived quintile. CONCLUSIONS Increasing socioeconomic deprivation is associated with a higher risk of developing STDR in people with diabetes. This underscores persistent health disparities linked to poverty, even within a country offering free universal health care. Further research is needed to address health equity concerns in socioeconomically deprived regions.

U2 - 10.2337/dc23-1626

DO - 10.2337/dc23-1626

M3 - Article

SN - 0149-5992

JO - Diabetes Care

JF - Diabetes Care

M1 - dc231626

ER -

Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy (STDR): A Population-Based Cohort Study in the U.K.

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this