Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes

Joanna Moss, Patricia Howlin, Richard Patrick Hastings, Sarah Beaumont, Gemma M Griffith, Jane Petty, Penny Tunnicliffe, Rachel Yates, Darrelle Villa, Chris Oliver

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n  =  19; mean age  = 10.35 years), Cornelia de Lange (CdLS; n  =  15; mean age  = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n  =  19; mean age  =  8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.

Original languageEnglish
Pages (from-to)262-283
Number of pages22
JournalAmerican Journal on Intellectual and Developmental Disabilities
Issue number4
Publication statusPublished - Jul 2013


  • Angelman syndrome
  • Autism spectrum disorder
  • Behavioral phenotypes
  • Cornelia de Lange syndrome
  • Cri du Chat syndrome
  • Social interaction skills
  • adolescent
  • adult
  • article
  • autism
  • cat cry syndrome
  • child
  • comorbidity
  • comparative study
  • de Lange syndrome
  • female
  • happy puppet syndrome
  • human
  • human relation
  • male
  • pathophysiology
  • phenotype
  • preschool child
  • psychologic test
  • psychological rating scale
  • qualitative research
  • questionnaire
  • social behavior
  • Adolescent
  • Adult
  • Angelman Syndrome
  • Child
  • Child Development Disorders, Pervasive
  • Child, Preschool
  • Comorbidity
  • Cri-du-Chat Syndrome
  • De Lange Syndrome
  • Female
  • Humans
  • Interpersonal Relations
  • Male
  • Phenotype
  • Psychiatric Status Rating Scales
  • Psychological Tests
  • Qualitative Research
  • Questionnaires
  • Social Behavior
  • Young Adult


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