SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma

David Wrench, Pamela Leighton, Christine F Skibola, Lucia Conde, Jean-Baptiste Cazier, Janet Matthews, Sameena Iqbal, Emanuela Carlotti, Csaba Bödör, Silvia Montoto, Maria Calaminici, John G Gribben, T Andrew Lister, Jude Fitzgibbon

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10⁻⁹) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.

Original languageEnglish
Pages (from-to)3147-50
Number of pages4
JournalBlood
Volume117
Issue number11
DOIs
Publication statusPublished - 17 Mar 2011

Keywords

  • Cell Transformation, Neoplastic
  • Chromosomes, Human, Pair 6
  • Great Britain
  • HLA Antigens
  • Humans
  • Lymphoma, Follicular
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Time Factors

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