TY - JOUR
T1 - Smoke exposure as a determinant of auto-antibody titre in AATD and COPD.
AU - Turner, Alice
AU - De Pablo, Paola
AU - Buckley, Christopher
AU - Bibi, Aishah
AU - Stockley, Robert
PY - 2010/6/4
Y1 - 2010/6/4
N2 - Liberation of elastin peptides from damaged lung may be a mechanism of autoimmune lung disease. Citrullination, and anti-citrullinated protein antibody formation occurs in smokers, but the role of smoking in autoantibody generation relevant to pulmonary disease is unclear. Anti-elastin, anti CCP and anti-MCV antibodies were measured in 257 subjects with alpha 1 antitrypsin deficiency (AATD) , 113 subjects with usual COPD and 22 healthy non-smokers. Levels were compared between groups, against phenotypic features, and against smoke exposure. Anti-elastin antibodies were higher in controls relative to AATD (p=0.008) and usual COPD (p
AB - Liberation of elastin peptides from damaged lung may be a mechanism of autoimmune lung disease. Citrullination, and anti-citrullinated protein antibody formation occurs in smokers, but the role of smoking in autoantibody generation relevant to pulmonary disease is unclear. Anti-elastin, anti CCP and anti-MCV antibodies were measured in 257 subjects with alpha 1 antitrypsin deficiency (AATD) , 113 subjects with usual COPD and 22 healthy non-smokers. Levels were compared between groups, against phenotypic features, and against smoke exposure. Anti-elastin antibodies were higher in controls relative to AATD (p=0.008) and usual COPD (p
U2 - 10.1183/09031936.00033710
DO - 10.1183/09031936.00033710
M3 - Article
C2 - 20525711
SN - 1399-3003
VL - 37
SP - 32
EP - 38
JO - The European respiratory journal
JF - The European respiratory journal
ER -