Small-world properties of the whole-brain functional networks in patients with obstructive sleep apnea‐hypopnea syndrome

Yaqing Huang, Yuting Liu, Dadi Zhao, Bin Liu, Huixin Zhang, Zhichun Huang, Ben Babourina-Brooks, Andrew C. Peet, Lingling Zhang, Yuan Feng, Ting Cheng, Ming Yang, Yu Sun

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Objective: To explore the small-world properties of brain functional networks in patients with obstructive sleep apnea−hypopnea syndrome (OSAHS) to aid diagnosis. Methods: A total of 29 OSAHS patients and 26 matched healthy volunteers were scanned with blood oxygen level−dependent functional magnetic resonance imaging (BOLD-fMRI) separately, and the whole brain was divided into 90 districts via automated anatomical labeling. The matrix Z was then built through a Fisher Z transformation. Two-sample t tests were applied to evaluate the changes in small-world properties in OSAHS patients compared to the control group. The properties included Eglobal, Elocal, and small-world parameters Lp, Cp, γ, λ, and σ. Results: Both groups satisfied the small-world properties (σ > 1) within the sparsity range of 0.1–0.2. However, compared with the control group, the OSAHS group performed significantly lower in Cp, Elocal, and Eglobal (p < 0.05) and higher in Lp (p < 0.05). The γ, σ, and λ values were not significantly different between the two groups. Conclusion: Both healthy and OSAHS patients exhibited small-world properties in functional networks, but a subset of these small-world properties in OSAHS patients performed differently. These changes will not only provide a new perspective for pathophysiological mechanisms of OSAHS but will also help in understanding the disease in terms of whole-brain functional networks.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalSleep Medicine
Volume62
DOIs
Publication statusPublished - Oct 2019

Bibliographical note

Funding Information:
The study was supported by the project of the Women's and Children's Health of Jiangsu Province (Grant No F201554), Technological Development of Nanjing City (2015sc511023), Six Talent Peaks Project in Jiangsu Province (WSN-192), China and Technological Development of Nanjing Medical University (2016NJMU089), China.

Funding Information:
The study was supported by the project of the Women's and Children's Health of Jiangsu Province (Grant No F201554 ), Technological Development of Nanjing City ( 2015sc511023 ), Six Talent Peaks Project in Jiangsu Province ( WSN-192 ), China and Technological Development of Nanjing Medical University ( 2016NJMU089 ), China.

Publisher Copyright:
© 2018 The Author(s)

Keywords

  • Brain's functional network
  • Magnetic resonance imaging
  • Obstructive sleep apnea-hypopnea syndrome (OSAHS)
  • Small-world

ASJC Scopus subject areas

  • Medicine(all)

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