The metabolism of sulfur has been widely studied with major progress in plant model systems. In plants and humans alike, activation occurs in canonical steps starting from the highly inert oxy-anion sulfate by the action of the enzymes ATP sulfurylase and APS kinase, resulting in the production of the atypical nucleotides adenosine-5’-phosphosulfate (APS) and PAPS (3’-phospho-APS). This review compares novel insights into structure, mechanism and regulation of plant ATP sulfurylases and APS kinases with findings from human sulfation pathways to highlight the benefit of “looking over the fence” and engaging in truly interdisciplinary research.
|Title of host publication||Molecular Physiology and Ecophysiology of Sulfur|
|Subtitle of host publication||Proceedings of the International Plant Sulfur Workshop|
|Number of pages||10|
|Volume||Ninth volume in a series encapsulating progress in sulfur research|
|Publication status||Published - 27 Nov 2015|