Small World: A Plant Perspective on Human Sulfate Activation

Jonathan Wolf Mueller, Nathanael O’Neill, Naeem Shafqat

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


The metabolism of sulfur has been widely studied with major progress in plant model systems. In plants and humans alike, activation occurs in canonical steps starting from the highly inert oxy-anion sulfate by the action of the enzymes ATP sulfurylase and APS kinase, resulting in the production of the atypical nucleotides adenosine-5’-phosphosulfate (APS) and PAPS (3’-phospho-APS). This review compares novel insights into structure, mechanism and regulation of plant ATP sulfurylases and APS kinases with findings from human sulfation pathways to highlight the benefit of “looking over the fence” and engaging in truly interdisciplinary research.
Original languageEnglish
Title of host publicationMolecular Physiology and Ecophysiology of Sulfur
Subtitle of host publicationProceedings of the International Plant Sulfur Workshop
Number of pages10
VolumeNinth volume in a series encapsulating progress in sulfur research
ISBN (Print)978-3-319-20137-5
Publication statusPublished - 27 Nov 2015


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