Sleep quality and cognitive impairment in older Chinese: Guangzhou Biobank Cohort Study

Xiao Qing  Ma; Chao Qiang Jiang; Lin Xu; Wei Sen Zhang; Feng  Zhu; Ya Li Jin; G Neil Thomas; Tai Hing Lam

doi:10.1093/ageing/afz120

Sleep quality and cognitive impairment in older Chinese: Guangzhou Biobank Cohort Study

Xiao Qing Ma, Chao Qiang Jiang, Lin Xu, Wei Sen Zhang, Feng Zhu, Ya Li Jin, G Neil Thomas, Tai Hing Lam

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

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Abstract

Background: Evidence concerning the relationship between sleep quality and cognitive impairment is limited and inconsistent.
Objective: To examine the association of sleep quality with memory impairment and poor cognitive function in a large sample of older Chinese.
Methods: 15,246 participants aged 50+ years of the Guangzhou Biobank Cohort Study who attended the second physical examination from 2008 to 2012 were included. Sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI), and cognitive performance was assessed using both Delayed Word Recall Test (DWRT) and Mini-Mental State Examination (MMSE). Memory impairment was defined by DWRT score <4 and poor cognitive function by MMSE score <25.
Results: After adjusting for potential confounders, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poor cognitive function with a dose-response pattern (both P for trend <0.001). The adjusted odds ratio (OR, 95% confidence interval (CI)) for poor cognitive function in those with sleep efficiency of 75-85%, 65-75%, and <65%, versus ≥85%, was 1.31 (1.12-1.53), 1.41 (1.16-1.73) and 1.33 (1.09-1.63), respectively. No association of the global PSQI score with memory impairment or poor cognitive function was found.
Conclusions: In older Chinese people, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poorer cognitive function.

Original language	English
Article number	afz120
Pages (from-to)	119-124
Journal	Age and Ageing
Volume	49
Issue number	1
DOIs	https://doi.org/10.1093/ageing/afz120
Publication status	Published - 28 Oct 2019

Keywords

Pittsburgh Sleep Quality Index
Sleep
cognition
depression
memory impairment
older people

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Ma_et_al__Sleep_quality_and_cognitive_impairment_in_older_Chinese_Age_and_Ageing_2019
This is a pre-copyedited, author-produced version of an article accepted for publication in Age and Ageing following peer review. The version of record Xiao Qing MA, Chao Qiang Jiang, Lin Xu, Wei Sen Zhang, Feng Zhu, Ya Li Jin, G Neil Thomas, Tai Hing Lam, Sleep quality and cognitive impairment in older Chinese: Guangzhou Biobank Cohort Study, Age and Ageing, , afz120, https://doi.org/10.1093/ageing/afz120 is available online at: https://academic.oup.com/ageing/advance-article/doi/10.1093/ageing/afz120/5607986
Accepted author manuscript, 172 KBLicence: Other (please specify with Rights Statement)

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title = "Sleep quality and cognitive impairment in older Chinese: Guangzhou Biobank Cohort Study",

abstract = "Background: Evidence concerning the relationship between sleep quality and cognitive impairment is limited and inconsistent.Objective: To examine the association of sleep quality with memory impairment and poor cognitive function in a large sample of older Chinese.Methods: 15,246 participants aged 50+ years of the Guangzhou Biobank Cohort Study who attended the second physical examination from 2008 to 2012 were included. Sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI), and cognitive performance was assessed using both Delayed Word Recall Test (DWRT) and Mini-Mental State Examination (MMSE). Memory impairment was defined by DWRT score <4 and poor cognitive function by MMSE score <25.Results: After adjusting for potential confounders, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poor cognitive function with a dose-response pattern (both P for trend <0.001). The adjusted odds ratio (OR, 95% confidence interval (CI)) for poor cognitive function in those with sleep efficiency of 75-85%, 65-75%, and <65%, versus ≥85%, was 1.31 (1.12-1.53), 1.41 (1.16-1.73) and 1.33 (1.09-1.63), respectively. No association of the global PSQI score with memory impairment or poor cognitive function was found.Conclusions: In older Chinese people, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poorer cognitive function.",

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author = "Ma, {Xiao Qing} and Jiang, {Chao Qiang} and Lin Xu and Zhang, {Wei Sen} and Feng Zhu and Jin, {Ya Li} and Thomas, {G Neil} and Lam, {Tai Hing}",

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AU - Lam, Tai Hing

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AB - Background: Evidence concerning the relationship between sleep quality and cognitive impairment is limited and inconsistent.Objective: To examine the association of sleep quality with memory impairment and poor cognitive function in a large sample of older Chinese.Methods: 15,246 participants aged 50+ years of the Guangzhou Biobank Cohort Study who attended the second physical examination from 2008 to 2012 were included. Sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI), and cognitive performance was assessed using both Delayed Word Recall Test (DWRT) and Mini-Mental State Examination (MMSE). Memory impairment was defined by DWRT score <4 and poor cognitive function by MMSE score <25.Results: After adjusting for potential confounders, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poor cognitive function with a dose-response pattern (both P for trend <0.001). The adjusted odds ratio (OR, 95% confidence interval (CI)) for poor cognitive function in those with sleep efficiency of 75-85%, 65-75%, and <65%, versus ≥85%, was 1.31 (1.12-1.53), 1.41 (1.16-1.73) and 1.33 (1.09-1.63), respectively. No association of the global PSQI score with memory impairment or poor cognitive function was found.Conclusions: In older Chinese people, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poorer cognitive function.

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Sleep quality and cognitive impairment in older Chinese: Guangzhou Biobank Cohort Study

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