TY - JOUR
T1 - Size dependent bioaccumulation and ecotoxicity of gold nanoparticles in an endobenthic invertebrate
T2 - the Tellinid clam Scrobicularia plana
AU - Pan, Jin-Fen
AU - Buffet, Pierre-Emmanuel
AU - Poirier, Laurence
AU - Amiard-Triquet, Claude
AU - Gilliland, Douglas
AU - Joubert, Yolaine
AU - Pilet, Paul
AU - Guibbolini, Marielle
AU - Risso de Faverney, Christine
AU - Roméo, Michèle
AU - Valsami-Jones, Eugenia
AU - Mouneyrac, Catherine
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2012/9
Y1 - 2012/9
N2 - Gold nanoparticles (AuNPs) have important technological applications resulting in an increased potential for release to the environment, and a greater possibility of toxicological effects. The marine bivalve Scrobicularia plana was exposed to AuNPs of size 5, 15 and 40 nm during a 16 d laboratory exposure at 100 μg Au L(-1). After exposure to AuNPs forming aggregates (>700 nm), the clams accumulated Au in their soft tissues. Biochemical (biomarkers) and behavioral (burrowing and feeding) responses were investigated. Au NPs were responsible of metallothionein induction (5, 40 nm), increased activities of catalase (15, 40 nm) and superoxide dismutase (40 nm) and of glutathione S-transferase by the three sizes of AuNPs indicating defense against oxidative stress. Exposure to AuNPs impaired burrowing behavior. However, it must be underlined that these effects were observed at a dose much higher than expected in the environment.
AB - Gold nanoparticles (AuNPs) have important technological applications resulting in an increased potential for release to the environment, and a greater possibility of toxicological effects. The marine bivalve Scrobicularia plana was exposed to AuNPs of size 5, 15 and 40 nm during a 16 d laboratory exposure at 100 μg Au L(-1). After exposure to AuNPs forming aggregates (>700 nm), the clams accumulated Au in their soft tissues. Biochemical (biomarkers) and behavioral (burrowing and feeding) responses were investigated. Au NPs were responsible of metallothionein induction (5, 40 nm), increased activities of catalase (15, 40 nm) and superoxide dismutase (40 nm) and of glutathione S-transferase by the three sizes of AuNPs indicating defense against oxidative stress. Exposure to AuNPs impaired burrowing behavior. However, it must be underlined that these effects were observed at a dose much higher than expected in the environment.
KW - Acetylcholinesterase
KW - Animals
KW - Behavior, Animal
KW - Biological Markers
KW - Bivalvia
KW - Catalase
KW - Glutathione Transferase
KW - Gold
KW - Metal Nanoparticles
KW - Metallothionein
KW - Oxidative Stress
KW - Superoxide Dismutase
KW - Thiobarbituric Acid Reactive Substances
KW - Water Pollutants, Chemical
U2 - 10.1016/j.envpol.2012.03.051
DO - 10.1016/j.envpol.2012.03.051
M3 - Article
C2 - 22595760
SN - 0269-7491
VL - 168
SP - 37
EP - 43
JO - Environmental Pollution
JF - Environmental Pollution
ER -