Size and shape affects the antimicrobial activity of quaternized nanoparticles

Maria Inam, Jeffrey C. Foster, Jingyi Gao, Yuanxiu Hong, Jianzhong Du, Andrew P. Dove, Rachel K. O'Reilly

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
114 Downloads (Pure)


Crystallization driven self‐assembly (CDSA) was utilized to prepare quaternized nanoparticles with spherical or platelet morphologies of different sizes to explore the effect of size and shape on their antibacterial activity. Small 2D platelets (< 1 µm) exhibited greater antibacterial activity than larger 2D platelets (ca. 4 µm), their corresponding spherical constructs, and unassembled polymer chains. This activity was dependent on the size, shape, and cell membrane structure of the bacteria.
Original languageEnglish
Number of pages5
JournalJournal of Polymer Science. Part A: Polymer Chemistry
Early online date18 Oct 2018
Publication statusE-pub ahead of print - 18 Oct 2018


  • biological activity
  • platelets
  • polymers
  • self-assembly
  • size effects


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