Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

Sally Fenton, Aamer Sandoo, George Metsios, Joan Duda, George Kitas, Jet Veldhuijzen van Zanten

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BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.

OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.

METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).

RESULTS: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = -3.25, p = .02, 95% CI [-6.07, -.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).

CONCLUSION: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

Original languageEnglish
Pages (from-to)57-60
JournalMicrovascular Research
Early online date21 Feb 2018
Publication statusPublished - May 2018


  • Journal Article


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