SiO2-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging

Yuwei Wang; Ziwei Zhang; Yasmin Abo-zeid; Joseph C. Bear; Gemma Louise Davies; Xiaodong Lei; Gareth R. Williams

doi:10.1016/j.jssc.2020.121291

SiO₂-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging

Yuwei Wang, Ziwei Zhang, Yasmin Abo-zeid, Joseph C. Bear, Gemma Louise Davies, Xiaodong Lei, Gareth R. Williams^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Layered gadolinium hydroxides (LGdH) have significant potential in simultaneous drug delivery and magnetic resonance imaging (MRI). In this work, we synthesized LGdH nanocomposites surface functionalised with SiO₂ nanodots (LGdH@SiO₂). We find these to have good dispersibility in cell culture medium, and a reduced tendency to aggregate compared to their uncoated analogue. Under the optimal reaction conditions, SiO₂ nanodots were evenly spread across the surface of the LGdH particles. We further intercalated ibuprofen (Ibu) and 5-fluorouracil (5FU) into LGdH@SiO₂, and explored the use of the resultant composites for drug delivery in vitro. While the SiO₂ coating could effectively reduce aggregation of the Ibu intercalate prepared by ion exchange from the parent LGdH, it was noted to increase aggregation in the case of the 5FU-loaded systems produced by coprecipitation. With a SiO₂ coating, 5FU release from the composite was almost zero-order at pH 7.4. The LGdH-5FU@SiO₂ composites can effectively inhibit the growth of A549 cells (a human adenocarcinoma cell line). In contrast, the Ibu-loaded materials are highly biocompatible. After SiO₂ modification, LGdH-5FU@SiO₂ retains the same proton relaxivity properties as LGdH-5FU, while LGdH-Ibu@SiO₂ becomes suitable for use as a negative contrast agent in MRI.

Original language	English
Article number	121291
Journal	Journal of Solid State Chemistry
Volume	286
DOIs	https://doi.org/10.1016/j.jssc.2020.121291
Publication status	Published - Jun 2020

Bibliographical note

Funding Information:
The authors would like to thank the China Scholarship Council for awarding Y.W. a scholarship to study at UCL, and the British Council and Science and Technology Development Fund in Egypt for awarding a Newton-Mosharafa Researcher Links Travel Grant to Y.A.-z. We are also grateful to Andrew Weston (UCL School of Pharmacy) for TEM data.

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

Drug delivery
Layered gadolinium hydroxides
Magnetic resonance imaging
Theranostics

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Condensed Matter Physics
Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.jssc.2020.121291

Cite this

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title = "SiO2-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging",

abstract = "Layered gadolinium hydroxides (LGdH) have significant potential in simultaneous drug delivery and magnetic resonance imaging (MRI). In this work, we synthesized LGdH nanocomposites surface functionalised with SiO2 nanodots (LGdH@SiO2). We find these to have good dispersibility in cell culture medium, and a reduced tendency to aggregate compared to their uncoated analogue. Under the optimal reaction conditions, SiO2 nanodots were evenly spread across the surface of the LGdH particles. We further intercalated ibuprofen (Ibu) and 5-fluorouracil (5FU) into LGdH@SiO2, and explored the use of the resultant composites for drug delivery in vitro. While the SiO2 coating could effectively reduce aggregation of the Ibu intercalate prepared by ion exchange from the parent LGdH, it was noted to increase aggregation in the case of the 5FU-loaded systems produced by coprecipitation. With a SiO2 coating, 5FU release from the composite was almost zero-order at pH 7.4. The LGdH-5FU@SiO2 composites can effectively inhibit the growth of A549 cells (a human adenocarcinoma cell line). In contrast, the Ibu-loaded materials are highly biocompatible. After SiO2 modification, LGdH-5FU@SiO2 retains the same proton relaxivity properties as LGdH-5FU, while LGdH-Ibu@SiO2 becomes suitable for use as a negative contrast agent in MRI.",

keywords = "Drug delivery, Layered gadolinium hydroxides, Magnetic resonance imaging, Theranostics",

author = "Yuwei Wang and Ziwei Zhang and Yasmin Abo-zeid and Bear, {Joseph C.} and Davies, {Gemma Louise} and Xiaodong Lei and Williams, {Gareth R.}",

note = "Funding Information: The authors would like to thank the China Scholarship Council for awarding Y.W. a scholarship to study at UCL, and the British Council and Science and Technology Development Fund in Egypt for awarding a Newton-Mosharafa Researcher Links Travel Grant to Y.A.-z. We are also grateful to Andrew Weston (UCL School of Pharmacy) for TEM data. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

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doi = "10.1016/j.jssc.2020.121291",

language = "English",

volume = "286",

journal = "Journal of Solid State Chemistry",

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T1 - SiO2-coated layered gadolinium hydroxides for simultaneous drug delivery and magnetic resonance imaging

AU - Wang, Yuwei

AU - Zhang, Ziwei

AU - Abo-zeid, Yasmin

AU - Bear, Joseph C.

AU - Davies, Gemma Louise

AU - Lei, Xiaodong

AU - Williams, Gareth R.

N1 - Funding Information: The authors would like to thank the China Scholarship Council for awarding Y.W. a scholarship to study at UCL, and the British Council and Science and Technology Development Fund in Egypt for awarding a Newton-Mosharafa Researcher Links Travel Grant to Y.A.-z. We are also grateful to Andrew Weston (UCL School of Pharmacy) for TEM data. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/6

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N2 - Layered gadolinium hydroxides (LGdH) have significant potential in simultaneous drug delivery and magnetic resonance imaging (MRI). In this work, we synthesized LGdH nanocomposites surface functionalised with SiO2 nanodots (LGdH@SiO2). We find these to have good dispersibility in cell culture medium, and a reduced tendency to aggregate compared to their uncoated analogue. Under the optimal reaction conditions, SiO2 nanodots were evenly spread across the surface of the LGdH particles. We further intercalated ibuprofen (Ibu) and 5-fluorouracil (5FU) into LGdH@SiO2, and explored the use of the resultant composites for drug delivery in vitro. While the SiO2 coating could effectively reduce aggregation of the Ibu intercalate prepared by ion exchange from the parent LGdH, it was noted to increase aggregation in the case of the 5FU-loaded systems produced by coprecipitation. With a SiO2 coating, 5FU release from the composite was almost zero-order at pH 7.4. The LGdH-5FU@SiO2 composites can effectively inhibit the growth of A549 cells (a human adenocarcinoma cell line). In contrast, the Ibu-loaded materials are highly biocompatible. After SiO2 modification, LGdH-5FU@SiO2 retains the same proton relaxivity properties as LGdH-5FU, while LGdH-Ibu@SiO2 becomes suitable for use as a negative contrast agent in MRI.

AB - Layered gadolinium hydroxides (LGdH) have significant potential in simultaneous drug delivery and magnetic resonance imaging (MRI). In this work, we synthesized LGdH nanocomposites surface functionalised with SiO2 nanodots (LGdH@SiO2). We find these to have good dispersibility in cell culture medium, and a reduced tendency to aggregate compared to their uncoated analogue. Under the optimal reaction conditions, SiO2 nanodots were evenly spread across the surface of the LGdH particles. We further intercalated ibuprofen (Ibu) and 5-fluorouracil (5FU) into LGdH@SiO2, and explored the use of the resultant composites for drug delivery in vitro. While the SiO2 coating could effectively reduce aggregation of the Ibu intercalate prepared by ion exchange from the parent LGdH, it was noted to increase aggregation in the case of the 5FU-loaded systems produced by coprecipitation. With a SiO2 coating, 5FU release from the composite was almost zero-order at pH 7.4. The LGdH-5FU@SiO2 composites can effectively inhibit the growth of A549 cells (a human adenocarcinoma cell line). In contrast, the Ibu-loaded materials are highly biocompatible. After SiO2 modification, LGdH-5FU@SiO2 retains the same proton relaxivity properties as LGdH-5FU, while LGdH-Ibu@SiO2 becomes suitable for use as a negative contrast agent in MRI.

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