Single-Molecule Analysis with Solid-State Nanopores

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26 Citations (Scopus)


Solid-state nanopores and nanopipettes are an exciting class of single-molecule sensors that has grown enormously over the last two decades. They offer a platform for testing fundamental concepts of stochasticity and transport at the nanoscale, for studying single-molecule biophysics and, increasingly, also for new analytical applications and in biomedical sensing. This review covers some fundamental aspects underpinning sensor operation and transport and, at the same time, it aims to put these into context as an analytical technique. It highlights new and recent developments and discusses some of the challenges lying ahead. Expected final online publication date for the Annual Review of Analytical Chemistry Volume 12 is June 12, 2019. Please see for revised estimates.

Original languageEnglish
Pages (from-to)371-387
JournalAnnual Review of Analytical Chemistry
Early online date24 Jan 2019
Publication statusPublished - 12 Jun 2019


  • Coulter
  • DNA
  • nanopipette
  • nanopore
  • resistive pulse sensing
  • sensing

ASJC Scopus subject areas

  • Analytical Chemistry


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