Projects per year
The Src family kinases (SFK) are a group of signalling molecules with important regulatory functions in inflammation and haemostasis. Leucocytes and platelets express multiple isoforms of the SFKs. Previous studies used broad-spectrum pharmacological inhibitors, or murine models deficient in multiple SFK isoforms, to demonstrate the functional consequences of deficiencies in SFK signalling. Here, we hypothesized that individual SFK operate in a non-redundant fashion in the thrombo-inflammatory recruitment of monocyte during atherosclerosis. Using in vitro adhesion assays and single SFK knockout mice crossed with the ApoE/ model of atherosclerosis, we find that SFK signalling regulates platelet-dependent recruitment of monocytes. However, loss of a single SFK, Fgr or Lyn, reduced platelet-mediated monocyte recruitment in vitro. This translated into a significant reduction in the burden of atherosclerotic disease in Fgr//ApoE/ or Lyn//ApoE/ animals. SFK signalling is not redundant in thrombo-inflammatory vascular disease and individual SFK may represent targets for therapeutic intervention.
|Number of pages||11|
|Journal||Journal of Cellular and Molecular Medicine|
|Publication status||Published - 4 Jul 2018|
- Src family kinases
FingerprintDive into the research topics of 'Signalling through Src Family Kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease'. Together they form a unique fingerprint.
- 2 Finished
Do Platelets Exacerbate the Atherogenic Process by Regulating the Recruitment, Differentiation and Inflammatory Function of Monocytes
Rainger, E., Nash, G. & Watson, S.
1/09/12 → 31/08/17
The Role of CD31 (PECAM-1) in Regulating the Burden and Phenotype of Atheroma Formed in the Apo-E Knockout Mouse
Rainger, E. & Buckley, C.
1/10/08 → 30/09/11