Side-effects of antipsychotic medication and health-related quality of life in schizophrenia

P. E. Bebbington, M. Angermeyer, J. M. Azorin, S. Marwaha, F. Marteau, M. Toumi

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Objective: This analysis used data from the large (n = 1208) European Schizophrenia Cohort to examine the association between subjective side-effects of antipsychotic medication and the Mental and Physical Composite Scores (MCS; PCS) of the SF-36 scale. Method: Relationships between the subjective evaluation of side-effects identified from the Subjective Side-Effects Scale and the adjusted mean score on the PCS and MCS were examined. Where appropriate, these associations of subjective side-effects were compared with those of the same side-effects measured objectively. Results: In this study, subjective side-effects of antipsychotic medication were linked either to both the PCS and the MCS or, in a few instances, to neither. Subjective evaluations of sexual side-effects were associated only with the MCS, those of sialorrhoea only with the PCS. Objective ratings of extrapyramidal side-effects were related neither to PCS nor to MCS. Conclusion: These data suggest that side-effects, whether subjective or objective, may need to be considered individually in relation to their impact on quality of life.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalActa Psychiatrica Scandinavica
Issue numberSUPPL. 438
Publication statusPublished - 1 Feb 2009


  • Quality of life
  • Schizophrenia
  • Side-effects

ASJC Scopus subject areas

  • Psychiatry and Mental health


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