TY - JOUR
T1 - Side-effects of antipsychotic medication and health-related quality of life in schizophrenia
AU - Bebbington, P. E.
AU - Angermeyer, M.
AU - Azorin, J. M.
AU - Marwaha, S.
AU - Marteau, F.
AU - Toumi, M.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Objective: This analysis used data from the large (n = 1208) European Schizophrenia Cohort to examine the association between subjective side-effects of antipsychotic medication and the Mental and Physical Composite Scores (MCS; PCS) of the SF-36 scale. Method: Relationships between the subjective evaluation of side-effects identified from the Subjective Side-Effects Scale and the adjusted mean score on the PCS and MCS were examined. Where appropriate, these associations of subjective side-effects were compared with those of the same side-effects measured objectively. Results: In this study, subjective side-effects of antipsychotic medication were linked either to both the PCS and the MCS or, in a few instances, to neither. Subjective evaluations of sexual side-effects were associated only with the MCS, those of sialorrhoea only with the PCS. Objective ratings of extrapyramidal side-effects were related neither to PCS nor to MCS. Conclusion: These data suggest that side-effects, whether subjective or objective, may need to be considered individually in relation to their impact on quality of life.
AB - Objective: This analysis used data from the large (n = 1208) European Schizophrenia Cohort to examine the association between subjective side-effects of antipsychotic medication and the Mental and Physical Composite Scores (MCS; PCS) of the SF-36 scale. Method: Relationships between the subjective evaluation of side-effects identified from the Subjective Side-Effects Scale and the adjusted mean score on the PCS and MCS were examined. Where appropriate, these associations of subjective side-effects were compared with those of the same side-effects measured objectively. Results: In this study, subjective side-effects of antipsychotic medication were linked either to both the PCS and the MCS or, in a few instances, to neither. Subjective evaluations of sexual side-effects were associated only with the MCS, those of sialorrhoea only with the PCS. Objective ratings of extrapyramidal side-effects were related neither to PCS nor to MCS. Conclusion: These data suggest that side-effects, whether subjective or objective, may need to be considered individually in relation to their impact on quality of life.
KW - Quality of life
KW - Schizophrenia
KW - Side-effects
UR - http://www.scopus.com/inward/record.url?scp=64349110340&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0447.2008.01310.x
DO - 10.1111/j.1600-0447.2008.01310.x
M3 - Article
C2 - 19132963
AN - SCOPUS:64349110340
SN - 0001-690X
VL - 119
SP - 22
EP - 28
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
IS - SUPPL. 438
ER -
