Short-acquisition-time JPRESS and its application to paediatric brain tumours

Dominic Carlin; Ben Babourina-Brooks; Theodoros N Arvanitis; Martin Wilson; Andrew C Peet

doi:10.1007/s10334-018-0716-6

Short-acquisition-time JPRESS and its application to paediatric brain tumours

Dominic Carlin, Ben Babourina-Brooks, Theodoros N Arvanitis, Martin Wilson, Andrew C Peet

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1 Citation (Scopus)

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Abstract

OBJECTIVE: To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.

MATERIALS AND METHODS: The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.

RESULTS: Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.

CONCLUSION: A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.

Original language	English
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Early online date	20 Nov 2018
DOIs	https://doi.org/10.1007/s10334-018-0716-6
Publication status	E-pub ahead of print - 20 Nov 2018

Keywords

Brain neoplasms
Magnetic resonance spectroscopy
Metabolism

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10.1007/s10334-018-0716-6Licence: Creative Commons: Attribution (CC BY)

Carlin_et_al_2018_Short_acquisition_time_JPRESS_Magnetic_Resonance_Materials_in_Physics_Biology_and_MedicineFinal published version, 3.39 MBLicence: Creative Commons: Attribution (CC BY)

Development and Evaluation of MR based Functional Imaging for the Enhanced Management of Childhood Cancer - A Childrens Cancer and Leukaemia Group Initiative
Peet, A. & Arvanitis, T.
Cancer Research UK
1/12/08 → 31/03/15
Project: Research
Lipids Detected by 1H Magnetic Resonance Spectroscopy as Brain Tumour Biomarkers
Peet, A., Arvanitis, T. & Cummins, C.
Medical Research Council
1/10/07 → 28/02/11
Project: Research Councils

Cite this

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title = "Short-acquisition-time JPRESS and its application to paediatric brain tumours",

abstract = "OBJECTIVE: To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.MATERIALS AND METHODS: The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.RESULTS: Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.CONCLUSION: A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.",

keywords = "Brain neoplasms, Magnetic resonance spectroscopy, Metabolism",

author = "Dominic Carlin and Ben Babourina-Brooks and Arvanitis, {Theodoros N} and Martin Wilson and Peet, {Andrew C}",

year = "2018",

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doi = "10.1007/s10334-018-0716-6",

language = "English",

journal = "Magnetic Resonance Materials in Physics, Biology and Medicine",

issn = "0968-5243",

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T1 - Short-acquisition-time JPRESS and its application to paediatric brain tumours

AU - Carlin, Dominic

AU - Babourina-Brooks, Ben

AU - Arvanitis, Theodoros N

AU - Wilson, Martin

AU - Peet, Andrew C

PY - 2018/11/20

Y1 - 2018/11/20

N2 - OBJECTIVE: To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.MATERIALS AND METHODS: The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.RESULTS: Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.CONCLUSION: A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.

AB - OBJECTIVE: To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.MATERIALS AND METHODS: The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.RESULTS: Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.CONCLUSION: A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.

KW - Brain neoplasms

KW - Magnetic resonance spectroscopy

KW - Metabolism

U2 - 10.1007/s10334-018-0716-6

DO - 10.1007/s10334-018-0716-6

M3 - Article

C2 - 30460431

SN - 0968-5243

JO - Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magnetic Resonance Materials in Physics, Biology and Medicine

ER -

Short-acquisition-time JPRESS and its application to paediatric brain tumours

Abstract

Keywords

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Projects

Development and Evaluation of MR based Functional Imaging for the Enhanced Management of Childhood Cancer - A Childrens Cancer and Leukaemia Group Initiative

Lipids Detected by 1H Magnetic Resonance Spectroscopy as Brain Tumour Biomarkers

Cite this