Projects per year
Abstract
OBJECTIVE: To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.
MATERIALS AND METHODS: The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.
RESULTS: Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.
CONCLUSION: A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.
Original language | English |
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Journal | Magnetic Resonance Materials in Physics, Biology and Medicine |
Early online date | 20 Nov 2018 |
DOIs | |
Publication status | E-pub ahead of print - 20 Nov 2018 |
Keywords
- Brain neoplasms
- Magnetic resonance spectroscopy
- Metabolism
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Dive into the research topics of 'Short-acquisition-time JPRESS and its application to paediatric brain tumours'. Together they form a unique fingerprint.Projects
- 2 Finished
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Development and Evaluation of MR based Functional Imaging for the Enhanced Management of Childhood Cancer - A Childrens Cancer and Leukaemia Group Initiative
Peet, A. (Principal Investigator) & Arvanitis, T. (Co-Investigator)
1/12/08 → 31/03/15
Project: Research
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Lipids Detected by 1H Magnetic Resonance Spectroscopy as Brain Tumour Biomarkers
Peet, A. (Principal Investigator), Arvanitis, T. (Co-Investigator) & Cummins, C. (Co-Investigator)
1/10/07 → 28/02/11
Project: Research Councils