Short-acquisition-time JPRESS and its application to paediatric brain tumours

Dominic Carlin, Ben Babourina-Brooks, Theodoros N Arvanitis, Martin Wilson, Andrew C Peet

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Abstract

OBJECTIVE: To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.

MATERIALS AND METHODS: The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.

RESULTS: Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.

CONCLUSION: A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.

Original languageEnglish
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Early online date20 Nov 2018
DOIs
Publication statusE-pub ahead of print - 20 Nov 2018

Keywords

  • Brain neoplasms
  • Magnetic resonance spectroscopy
  • Metabolism

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