Shared functional connectome fingerprints following ritualistic ayahuasca intake

Pablo Mallaroni*, Natasha L. Mason, Lilian Kloft, Johannes T. Reckweg, Kim van Oorsouw, Stefan W. Toennes, Hanna M. Tolle, Enrico Amico, Johannes G. Ramaekers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such “fingerprints” persist under altered states of consciousness is unknown. Ayahuasca is a potent serotonergic psychedelic which produces a widespread dysregulation of functional connectivity. Used communally in religious ceremonies, its shared use may highlight relevant novel interactions between mental state and functional connectome (FC) idiosyncrasy. Using 7T fMRI, we assessed resting-state static and dynamic FCs for 21 Santo Daime members after collective ayahuasca intake in an acute, within-subject study. Here, connectome fingerprinting revealed FCs showed reduced idiosyncrasy, accompanied by a spatiotemporal reallocation of keypoint edges. Importantly, we show that interindividual differences in higher-order FC motifs are relevant to experiential phenotypes, given that they can predict perceptual drug effects. Collectively, our findings offer an example of how individualised connectivity markers can be used to trace a subject's FC across altered states of consciousness.

Original languageEnglish
Article number120480
Number of pages16
JournalNeuroImage
Volume285
Early online date6 Dec 2023
DOIs
Publication statusPublished - Jan 2024

Bibliographical note

Publisher Copyright:
© 2023 The Author(s)

Keywords

  • Ayahuasca
  • Connectome fingerprints
  • fMRI
  • Individual differences
  • Psychedelics,5-HT2A

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Fingerprint

Dive into the research topics of 'Shared functional connectome fingerprints following ritualistic ayahuasca intake'. Together they form a unique fingerprint.

Cite this