SF-1: A critical mediator of steroidogenesis

Marit Bakke; Liping Zhao; Neil A. Hanley; Keith L. Parker

doi:10.1016/S0303-7207(00)00384-1

SF-1: A critical mediator of steroidogenesis

Marit Bakke, Liping Zhao, Neil A. Hanley, Keith L. Parker

Medicine and Health

Research output: Contribution to journal › Article › peer-review

Abstract

Studies in knockout mice have established that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays essential roles in the development and function of the primary steroidogenic organs. These SF-1 knockout mice lacked adrenal glands and gonads, causing adrenocortical insufficiency and sex reversal of their internal and external genitalia. They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic-pituitary-steroidogenic organ axis. Ongoing experiments are directed at developing methods to inactivate SF-1 in a tissue-specific manner. Copyright © 2001 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Molecular and Cellular Endocrinology
Volume	171
Issue number	1-2
DOIs	https://doi.org/10.1016/S0303-7207(00)00384-1
Publication status	Published - 22 Jan 2001

Keywords

Critical mediator
SF-1
Steroidogenesis

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10.1016/S0303-7207(00)00384-1

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title = "SF-1: A critical mediator of steroidogenesis",

abstract = "Studies in knockout mice have established that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays essential roles in the development and function of the primary steroidogenic organs. These SF-1 knockout mice lacked adrenal glands and gonads, causing adrenocortical insufficiency and sex reversal of their internal and external genitalia. They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic-pituitary-steroidogenic organ axis. Ongoing experiments are directed at developing methods to inactivate SF-1 in a tissue-specific manner. Copyright {\textcopyright} 2001 Elsevier Science Ireland Ltd.",

keywords = "Critical mediator, SF-1, Steroidogenesis",

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AU - Hanley, Neil A.

AU - Parker, Keith L.

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N2 - Studies in knockout mice have established that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays essential roles in the development and function of the primary steroidogenic organs. These SF-1 knockout mice lacked adrenal glands and gonads, causing adrenocortical insufficiency and sex reversal of their internal and external genitalia. They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic-pituitary-steroidogenic organ axis. Ongoing experiments are directed at developing methods to inactivate SF-1 in a tissue-specific manner. Copyright © 2001 Elsevier Science Ireland Ltd.

AB - Studies in knockout mice have established that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays essential roles in the development and function of the primary steroidogenic organs. These SF-1 knockout mice lacked adrenal glands and gonads, causing adrenocortical insufficiency and sex reversal of their internal and external genitalia. They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic-pituitary-steroidogenic organ axis. Ongoing experiments are directed at developing methods to inactivate SF-1 in a tissue-specific manner. Copyright © 2001 Elsevier Science Ireland Ltd.

KW - Critical mediator

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KW - Steroidogenesis

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DO - 10.1016/S0303-7207(00)00384-1

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ER -

SF-1: A critical mediator of steroidogenesis

Abstract

Keywords

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