Serum test for assessing patients with Bence Jones Myeloma

Arthur Bradwell, HD Carr-Smith, Graham Mead, Timothy Harvey, Mark Drayson

Research output: Contribution to journalArticle

234 Citations (Scopus)


Bence Jones protein in urine (immunoglobulin free-light-chains) is characteristic of light-chain multiple myeloma. We aimed to compare a quantitative immunoassay for serum free-light-chains with urine tests. Of 224 patients with light-chain myeloma tested at entry to clinical trials, all were correctly identified from serum samples. During monitoring of 82 patients, changes, in serum and urine tree-light-chains corresponded, but urine became negative for free-light-chains in 26 patients, whereas it remained abnormal in serum in 73 patients. Serum assays could replace Bence Jones protein urine tests for patients with light-chain multiple myeloma.
Original languageEnglish
Pages (from-to)489-91
Number of pages3
Issue number8
Publication statusPublished - 1 Jan 2003


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