Serum Resistin Levels and Related Genetic Variants Are Associated With Bone Mineral Density in Postmenopausal Women

Sundus Tariq; Saba Tariq; Saba Khaliq; Khalid Parvez Lone

doi:10.3389/fendo.2022.868120

Serum Resistin Levels and Related Genetic Variants Are Associated With Bone Mineral Density in Postmenopausal Women

Sundus Tariq^*, Saba Tariq^*, Saba Khaliq, Khalid Parvez Lone

^*Corresponding author for this work

Metabolism and Systems Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

27 Downloads (Pure)

Abstract

Background: Osteoporosis is a multifactorial disorder and a number of genetic variants or loci responsible for bone mineral density (BMD) have been identified. Resistin, a novel adipokine has diverse role in human body including its function in bone remodeling. The objective of this study was to see the association of serum resistin levels and related genetic variants (rs3931020, rs13144478) with BMD in postmenopausal females.

Methods: This comparative analytical study was conducted on postmenopausal osteoporotic (n=101), osteopenic (n=77) and non-osteoporotic (n=74) females. For comparison and correlational analysis, Kruskal-Wallis test and Spearman’s rho correlation were used respectively. Hardy-Weinberg equilibrium (HWE) was calculated by using Chi-square test (χ²).

Results: There was significant difference in the serum levels of resistin (p <0.001), among the three groups. Significant negative correlation of resistin was observed with BMD at various sites. Serum resistin levels were significantly low in the rs3931020 AA homozygous genotype (p = 0.010), and significantly high in the rs13144478 AT heterozygous genotype (p = 0.020), BMD at all sites except left femoral neck was significantly high in rs3931020 AA genotype, while BMD at lumbar spine, left hip and total BMD were significantly low in the rs13144478 TT homozygotes.

Conclusion: High serum resistin levels are associated with low BMD and single nucleotide variation in rs3931020 and rs13144478 may lead to high serum resistin levels and low bone mineral density. Resistin can serve as a new genetic marker, potential therapeutic target and predictor of osteoporosis.

Original language	English
Article number	868120
Number of pages	10
Journal	Frontiers in Endocrinology
Volume	13
DOIs	https://doi.org/10.3389/fendo.2022.868120
Publication status	Published - 5 Aug 2022

Bibliographical note

Funding Information:
We acknowledge the technical staff of Madina teaching hospital and Pakistan institute of nuclear medicine for helping in performing biochemical analysis and DXA measurements. The research is supported by grant from Higher Education Commission, Pakistan under grant number: 8530/Punjab/NRPU/R&D/HEC/2017.

Publisher Copyright:
Copyright © 2022 Tariq, Tariq, Khaliq and Lone.

Keywords

adipokine
DXA (Dual-energy X-ray Absorptiometry)
osteoporosis
resistin
single nucleotide variants

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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TariqS2022SerumFinal published version, 2.38 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Serum Resistin Levels and Related Genetic Variants Are Associated With Bone Mineral Density in Postmenopausal Women",

abstract = "Background: Osteoporosis is a multifactorial disorder and a number of genetic variants or loci responsible for bone mineral density (BMD) have been identified. Resistin, a novel adipokine has diverse role in human body including its function in bone remodeling. The objective of this study was to see the association of serum resistin levels and related genetic variants (rs3931020, rs13144478) with BMD in postmenopausal females. Methods: This comparative analytical study was conducted on postmenopausal osteoporotic (n=101), osteopenic (n=77) and non-osteoporotic (n=74) females. For comparison and correlational analysis, Kruskal-Wallis test and Spearman{\textquoteright}s rho correlation were used respectively. Hardy-Weinberg equilibrium (HWE) was calculated by using Chi-square test (χ2). Results: There was significant difference in the serum levels of resistin (p <0.001), among the three groups. Significant negative correlation of resistin was observed with BMD at various sites. Serum resistin levels were significantly low in the rs3931020 AA homozygous genotype (p = 0.010), and significantly high in the rs13144478 AT heterozygous genotype (p = 0.020), BMD at all sites except left femoral neck was significantly high in rs3931020 AA genotype, while BMD at lumbar spine, left hip and total BMD were significantly low in the rs13144478 TT homozygotes. Conclusion: High serum resistin levels are associated with low BMD and single nucleotide variation in rs3931020 and rs13144478 may lead to high serum resistin levels and low bone mineral density. Resistin can serve as a new genetic marker, potential therapeutic target and predictor of osteoporosis.",

keywords = "adipokine, DXA (Dual-energy X-ray Absorptiometry), osteoporosis, resistin, single nucleotide variants",

author = "Sundus Tariq and Saba Tariq and Saba Khaliq and Lone, {Khalid Parvez}",

note = "Funding Information: We acknowledge the technical staff of Madina teaching hospital and Pakistan institute of nuclear medicine for helping in performing biochemical analysis and DXA measurements. The research is supported by grant from Higher Education Commission, Pakistan under grant number: 8530/Punjab/NRPU/R&D/HEC/2017. Publisher Copyright: Copyright {\textcopyright} 2022 Tariq, Tariq, Khaliq and Lone.",

year = "2022",

month = aug,

day = "5",

doi = "10.3389/fendo.2022.868120",

language = "English",

volume = "13",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers",

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TY - JOUR

T1 - Serum Resistin Levels and Related Genetic Variants Are Associated With Bone Mineral Density in Postmenopausal Women

AU - Tariq, Sundus

AU - Tariq, Saba

AU - Khaliq, Saba

AU - Lone, Khalid Parvez

N1 - Funding Information: We acknowledge the technical staff of Madina teaching hospital and Pakistan institute of nuclear medicine for helping in performing biochemical analysis and DXA measurements. The research is supported by grant from Higher Education Commission, Pakistan under grant number: 8530/Punjab/NRPU/R&D/HEC/2017. Publisher Copyright: Copyright © 2022 Tariq, Tariq, Khaliq and Lone.

PY - 2022/8/5

Y1 - 2022/8/5

N2 - Background: Osteoporosis is a multifactorial disorder and a number of genetic variants or loci responsible for bone mineral density (BMD) have been identified. Resistin, a novel adipokine has diverse role in human body including its function in bone remodeling. The objective of this study was to see the association of serum resistin levels and related genetic variants (rs3931020, rs13144478) with BMD in postmenopausal females. Methods: This comparative analytical study was conducted on postmenopausal osteoporotic (n=101), osteopenic (n=77) and non-osteoporotic (n=74) females. For comparison and correlational analysis, Kruskal-Wallis test and Spearman’s rho correlation were used respectively. Hardy-Weinberg equilibrium (HWE) was calculated by using Chi-square test (χ2). Results: There was significant difference in the serum levels of resistin (p <0.001), among the three groups. Significant negative correlation of resistin was observed with BMD at various sites. Serum resistin levels were significantly low in the rs3931020 AA homozygous genotype (p = 0.010), and significantly high in the rs13144478 AT heterozygous genotype (p = 0.020), BMD at all sites except left femoral neck was significantly high in rs3931020 AA genotype, while BMD at lumbar spine, left hip and total BMD were significantly low in the rs13144478 TT homozygotes. Conclusion: High serum resistin levels are associated with low BMD and single nucleotide variation in rs3931020 and rs13144478 may lead to high serum resistin levels and low bone mineral density. Resistin can serve as a new genetic marker, potential therapeutic target and predictor of osteoporosis.

AB - Background: Osteoporosis is a multifactorial disorder and a number of genetic variants or loci responsible for bone mineral density (BMD) have been identified. Resistin, a novel adipokine has diverse role in human body including its function in bone remodeling. The objective of this study was to see the association of serum resistin levels and related genetic variants (rs3931020, rs13144478) with BMD in postmenopausal females. Methods: This comparative analytical study was conducted on postmenopausal osteoporotic (n=101), osteopenic (n=77) and non-osteoporotic (n=74) females. For comparison and correlational analysis, Kruskal-Wallis test and Spearman’s rho correlation were used respectively. Hardy-Weinberg equilibrium (HWE) was calculated by using Chi-square test (χ2). Results: There was significant difference in the serum levels of resistin (p <0.001), among the three groups. Significant negative correlation of resistin was observed with BMD at various sites. Serum resistin levels were significantly low in the rs3931020 AA homozygous genotype (p = 0.010), and significantly high in the rs13144478 AT heterozygous genotype (p = 0.020), BMD at all sites except left femoral neck was significantly high in rs3931020 AA genotype, while BMD at lumbar spine, left hip and total BMD were significantly low in the rs13144478 TT homozygotes. Conclusion: High serum resistin levels are associated with low BMD and single nucleotide variation in rs3931020 and rs13144478 may lead to high serum resistin levels and low bone mineral density. Resistin can serve as a new genetic marker, potential therapeutic target and predictor of osteoporosis.

KW - adipokine

KW - DXA (Dual-energy X-ray Absorptiometry)

KW - osteoporosis

KW - resistin

KW - single nucleotide variants

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U2 - 10.3389/fendo.2022.868120

DO - 10.3389/fendo.2022.868120

M3 - Article

AN - SCOPUS:85136463715

SN - 1664-2392

VL - 13

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 868120

ER -

Serum Resistin Levels and Related Genetic Variants Are Associated With Bone Mineral Density in Postmenopausal Women

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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