Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

W.B. Dunn; I. Spasic; D.B. Kell; D.I. Broadhurst; D.I. Ellis; S.M. Deepak; M.H. Buch; L. Neyses; N. Brooks; G. McDowell

doi:10.1007/s11306-007-0063-5

Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

W.B. Dunn, I. Spasic, D.B. Kell, D.I. Broadhurst, D.I. Ellis, S.M. Deepak, M.H. Buch, L. Neyses, N. Brooks, G. McDowell

Biosciences

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158 Citations (Scopus)

Abstract

There is intense interest in the identification of novel biomarkers which improve the diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF<40% plus signs and symptoms of failure) and 57 controls were analyzed by gas chromatography - time of flight - mass spectrometry and the raw data reduced to 272 statistically robust metabolite peaks. 38 peaks showed a significant difference between case and control (p

Original language	English
Pages (from-to)	413-426
Number of pages	14
Journal	Metabolomics
Volume	3
Issue number	4
DOIs	https://doi.org/10.1007/s11306-007-0063-5
Publication status	Published - 1 Dec 2007

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title = "Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate",

abstract = "There is intense interest in the identification of novel biomarkers which improve the diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF<40\% plus signs and symptoms of failure) and 57 controls were analyzed by gas chromatography - time of flight - mass spectrometry and the raw data reduced to 272 statistically robust metabolite peaks. 38 peaks showed a significant difference between case and control (p ",

author = "W.B. Dunn and I. Spasic and D.B. Kell and D.I. Broadhurst and D.I. Ellis and S.M. Deepak and M.H. Buch and L. Neyses and N. Brooks and G. McDowell",

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AU - Spasic, I.

AU - Kell, D.B.

AU - Broadhurst, D.I.

AU - Ellis, D.I.

AU - Deepak, S.M.

AU - Buch, M.H.

AU - Neyses, L.

AU - Brooks, N.

AU - McDowell, G.

PY - 2007/12/1

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AB - There is intense interest in the identification of novel biomarkers which improve the diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF<40% plus signs and symptoms of failure) and 57 controls were analyzed by gas chromatography - time of flight - mass spectrometry and the raw data reduced to 272 statistically robust metabolite peaks. 38 peaks showed a significant difference between case and control (p

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DO - 10.1007/s11306-007-0063-5

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JO - Metabolomics

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Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

Abstract

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