Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

W.B. Dunn, I. Spasic, D.B. Kell, D.I. Broadhurst, D.I. Ellis, S.M. Deepak, M.H. Buch, L. Neyses, N. Brooks, G. McDowell

Research output: Contribution to journalArticlepeer-review

158 Citations (Scopus)

Abstract

There is intense interest in the identification of novel biomarkers which improve the diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF<40% plus signs and symptoms of failure) and 57 controls were analyzed by gas chromatography - time of flight - mass spectrometry and the raw data reduced to 272 statistically robust metabolite peaks. 38 peaks showed a significant difference between case and control (p
Original languageEnglish
Pages (from-to)413-426
Number of pages14
JournalMetabolomics
Volume3
Issue number4
DOIs
Publication statusPublished - 1 Dec 2007

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