TY - JOUR
T1 - Serum free immunoglobulin light chain evaluation as a marker of impact from intraclonal heterogeneity on myeloma outcome
AU - Brioli, A.
AU - Giles, H.
AU - Pawlyn, C.
AU - Campbell, J.P.
AU - Kaiser, M.F.
AU - Melchor, L.
AU - Jackson, G.H.
AU - Gregory, W.M.
AU - Owen, R.G.
AU - Child, J.A.
AU - Davies, F.E.
AU - Cavo, M.
AU - Drayson, M.T.
AU - Morgan, G.J.
PY - 2014/5/29
Y1 - 2014/5/29
N2 - Intraclonal heterogeneity was recently described in multiple myeloma (MM), but its full impact on disease progression and relapse has not been entirely explored. The immunoglobulin type produced by myeloma cells provides an excellent marker to follow changes in clonal substructure over time.We have prospectively evaluated serial paraprotein and serum free light chain (FLC) measurements and found that 258 of 520 and 54 of 520 patients who presented with a whole paraprotein relapsed with paraprotein only (PO) and "FLC escape," respectively. The median overall survival of PO patients was longer, when compared with patients whose relapse manifested as an increase in FLC both alone and with a whole paraprotein, as a result of a significantly shorter survival from relapse of the latter groups. These observations fit a model in which 1 clone is able to produce a complete antibody, whereas the other secretes only FLC; the type of relapse represents the outgrowth of different clones, some ofwhich are more resistant to therapy. To our knowledge, this is the largest series describing patients who have relapsed with FLC escape and highlights the importance ofmonitoring FLC when there is a suspicion of clinical relapse. This study was registered at www.isrctn.org as ISRCTN68454111.
AB - Intraclonal heterogeneity was recently described in multiple myeloma (MM), but its full impact on disease progression and relapse has not been entirely explored. The immunoglobulin type produced by myeloma cells provides an excellent marker to follow changes in clonal substructure over time.We have prospectively evaluated serial paraprotein and serum free light chain (FLC) measurements and found that 258 of 520 and 54 of 520 patients who presented with a whole paraprotein relapsed with paraprotein only (PO) and "FLC escape," respectively. The median overall survival of PO patients was longer, when compared with patients whose relapse manifested as an increase in FLC both alone and with a whole paraprotein, as a result of a significantly shorter survival from relapse of the latter groups. These observations fit a model in which 1 clone is able to produce a complete antibody, whereas the other secretes only FLC; the type of relapse represents the outgrowth of different clones, some ofwhich are more resistant to therapy. To our knowledge, this is the largest series describing patients who have relapsed with FLC escape and highlights the importance ofmonitoring FLC when there is a suspicion of clinical relapse. This study was registered at www.isrctn.org as ISRCTN68454111.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84901717964&partnerID=8YFLogxK
U2 - 10.1182/blood-2013-12-542662
DO - 10.1182/blood-2013-12-542662
M3 - Article
C2 - 24733348
AN - SCOPUS:84901717964
SN - 0006-4971
VL - 123
SP - 3414
EP - 3419
JO - Blood
JF - Blood
IS - 22
ER -