Sequence-specific synthesis of macromolecules using DNA-templated chemistry

Phillip J. Milnes, Mireya L. McKee, Jonathan Bath, Lijiang Song, Eugen Stulz, Andrew J. Turberfield, Rachel K. O'Reilly

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.
Original languageEnglish
Pages (from-to)5614-5616
JournalChemical Communications
Issue number45
Publication statusPublished - 17 Apr 2012


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