Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter.

M Schué; LG Dover; Gurdyal Besra; J Parkhill; NL Brown

doi:10.1128/JB.01063-08

Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter.

M Schué, LG Dover, Gurdyal Besra, J Parkhill, NL Brown

Biosciences

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Abstract

In this study, we report the DNA sequence and biological analysis of a mycobacterial mercury resistance operon encoding a novel Hg(2+) transporter. MerH was found to transport mercuric ions in Escherichia coli via a pair of essential cysteine residues but only when coexpressed with the mercuric reductase.

Original language	English
Pages (from-to)	439-44
Number of pages	6
Journal	Journal of Bacteriology
Volume	191
Issue number	1
DOIs	https://doi.org/10.1128/JB.01063-08
Publication status	Published - 1 Jan 2009

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10.1128/JB.01063-08

MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope
Besra, D., Lammas, T. & Minnikin, D.
Medical Research Council
1/02/06 → 31/01/11
Project: Research Councils

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title = "Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter.",

abstract = "In this study, we report the DNA sequence and biological analysis of a mycobacterial mercury resistance operon encoding a novel Hg(2+) transporter. MerH was found to transport mercuric ions in Escherichia coli via a pair of essential cysteine residues but only when coexpressed with the mercuric reductase.",

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AU - Schué, M

AU - Dover, LG

AU - Besra, Gurdyal

AU - Parkhill, J

AU - Brown, NL

PY - 2009/1/1

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N2 - In this study, we report the DNA sequence and biological analysis of a mycobacterial mercury resistance operon encoding a novel Hg(2+) transporter. MerH was found to transport mercuric ions in Escherichia coli via a pair of essential cysteine residues but only when coexpressed with the mercuric reductase.

AB - In this study, we report the DNA sequence and biological analysis of a mycobacterial mercury resistance operon encoding a novel Hg(2+) transporter. MerH was found to transport mercuric ions in Escherichia coli via a pair of essential cysteine residues but only when coexpressed with the mercuric reductase.

U2 - 10.1128/JB.01063-08

DO - 10.1128/JB.01063-08

M3 - Article

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SN - 0021-9193

VL - 191

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JO - Journal of Bacteriology

JF - Journal of Bacteriology

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ER -

Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter.

Abstract

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Projects

MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope

Cite this